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Zu "K04608" wurden 24 Artikel gefunden!
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Artikelnummer: Cay21450-25
(S)-MCPG is an antagonist of metabotropic glutamate receptors (mGluRs) and the active component of (±)-MCPG, which is selective for Group I and Group II mGluRs. (S)-MCPG inhibits motoneuron depolarization induced by 1-amino-1,3-dicarboxycyclopentane (ACPD) in neonatal rat spinal cord in vitro and ACPD-induced...
Schlagworte: | (+)-MCPG, (+)-alpha-methyl-4-Carboxyphenylglycine, (S)-alpha-methyl-4-Carboxyphenylglycine,... |
Anwendung: | Non-selective group I/group II metabotropic glutamate receptor antagonist |
CAS | 150145-89-4 |
MW: | 209.2 D |
ab 89,00 €
Artikelnummer: Cay18862-1
MMPIP is a reversible allosteric antagonist of the metabotropic glutamate receptor 7 (mGluR7) that blocks agonist-induced calcium mobilization (IC50 = 26 nM). It does not affect other mGlu receptors. The modulation of mGluR7 by MMPIP is context dependent, in that it is not observed in all known mGluR7 signaling...
Schlagworte: | 6-(4-methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one, monohydrochloride |
Anwendung: | mGluR7 antagonist |
CAS | 1215566-78-1 |
MW: | 369.8 D |
ab 92,00 €
Artikelnummer: Cay22072-1
DCPG is a selective agonist of the class III metabotropic glutamate receptor 8 (mGluR8), with an EC50 value of 31 nM for inhibiting forskolin-stimulated cAMP formation in AV12-664 cells expressing human mGluR8. It is selective for mGluR8 over other mGluRs (EC50s = >3.5 µM for mGluR1-7). In vitro, DCPG (1 µM)...
Schlagworte: | (S)-3,4-DCPG, 4-[(S)-aminocarboxymethyl]-1,2-benzenedicarboxylic acid |
Anwendung: | mGluR8a agonist |
CAS | 201730-11-2 |
MW: | 239.2 D |
ab 43,00 €
Artikelnummer: Cay78010-10
ACPT-I is an agonist of the group III metabotropic glutamate receptors (mGluRs) mGluR4a and mGluR8 (EC50s = 7.2 and 8.2 µM, respectively) that has no effect on mGluR1a or mGluR2. It has diverse biological activity, including neuroprotective, anticonvulsant, and anxiolytic-like effects. ACPT-I (1-200 µM) reduces cell...
Schlagworte: | (4beta)--amino-1alpha,2alpha,4-cyclopentanetricarboxylic acid |
Anwendung: | mGluR4a / mGluR8 agonist |
CAS | 194918-76-8 |
MW: | 217.2 D |
ab 60,00 €
Artikelnummer: Cay16151-10
O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 µM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.Formal Name:...
Schlagworte: | Dexfosfoserine, L-Serine-O-Phosphate, L-SOP, O-phosphono-L-serine |
Anwendung: | mGluR4 / mGluR6 agonist |
CAS | 407-41-0 |
MW: | 185.1 D |
ab 34,00 €
Artikelnummer: Cay19095-1
XAP044 is an antagonist of the metabotropic glutamate (mGlu) receptor 7 (mGluR7), inhibiting lateral amygdala long term potentiation in brain slices from wild-type mice with an IC50 value of 88 nM. This effect is absent in mGluR7-deficient mice. XAP044 demonstrates good brain penetrance, producing wide spectrum...
Schlagworte: | 7-hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one |
Anwendung: | mGluR7 antagonist |
CAS | 196928-50-4 |
MW: | 380.1 D |
ab 43,00 €
Artikelnummer: Cay28849-5
(±)-trans-ACPD is an agonist of metabotropic glutamate receptors (mGluRs, EC50s = 15, 2, 40, 23, and 82 µM for mGluR1, -2, -3, -5, and -6, respectively, in CHO cells expressing recombinant receptors). It also activates mGluR4 in baby hamster kidney cells with an EC50 value of approximately 800 µM. (±)-trans-ACPD...
Schlagworte: | (1R,3S)-1-aminocyclopentane-1,3-dicarboxylic acid |
Anwendung: | mGluR agonist |
CAS | 67684-64-4 |
MW: | 173.2 D |
ab 50,00 €
Artikelnummer: Cay34362-5
CPPG is an antagonist of group II and group III metabotropic glutamate receptors (mGluRs). It reverses inhibition of forskolin-induced cAMP accumulation induced by the mGluR group II selective agonist L-CCG-1 or the mGluR group III-selective agonist L-AP4 (Cay-14538) in rat cerebrocortical slices (IC50s = 46.2 and...
Schlagworte: | alpha-Cyclopropyl-4-phosphonophenylglycine, alpha-amino-alpha-cyclopropyl-4-phosphono-benzeneacetic acid |
Anwendung: | Group II and group III mGluR antagonist |
CAS | 183364-82-1 |
MW: | 271.2 D |
ab 50,00 €
Artikelnummer: ATA-HPA014511.100
Protein function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Signaling...
Schlagworte: | Anti-GRM6, Anti-mGluR6, Anti-GPRC1F, Anti-Metabotropic glutamate receptor 6 |
Anwendung: | IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 335,00 €
Artikelnummer: ELK-ES5678.100
glutamate metabotropic receptor 6(GRM6) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in...
Schlagworte: | Anti-GRM6, Anti-GPRC1F, Anti-mGluR6, Anti-Metabotropic glutamate receptor 6, mGluR-6 rabbit pAb |
Anwendung: | WB, IHC, IF, ELISA |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, rat, mouse, |
ab 169,00 €
Artikelnummer: VHPS-3873
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
Schlagworte: | GRM6, mGluR6, GPRC1F, Metabotropic glutamate receptor 6 |
Anwendung: | RNA quantification |
43,00 €
Artikelnummer: VHPS-3874
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
Schlagworte: | GRM7, mGluR7, GPRC1G, Metabotropic glutamate receptor 7 |
Anwendung: | RNA quantification |
43,00 €