DAPT

Description: DAPT (LY-374973) is a gamma-secretase inhibitor that inhibits total Abeta and Abeta42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis. Target: Apoptosis, Autophagy, Gamma-secretase, Beta Amyloid. Smiles: C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@H](C(=O)OC(C)(C)C)c1ccccc1. References: Jiang LY, et al. gamma-Secretase Inhibitor, DAPT Inhibits Self-renewal and Stemness Maintenance of Ovarian Cancer Stem-like Cells In Vitro. Chin J Cancer Res. 2011 Jun,23(2):140-6.