Dapiprazole (hydrochloride)

Dapiprazole is an alpha-adrenergic receptor (alpha-AR) antagonist. It inhibits norepinephrine-induced contractions in rat vas deferens, guinea pig spleen, and rat aorta, regions that express high levels of alpha1A-AR, alpha1B-AR, and alpha1D-ARs, respectively (pA2s = 7.93, 7.13, and 8.26, respectively). It also inhibits contractions induced by histamine, angiotensin II, pentagastrin (Cay-28546), carbamoylcholine (carbachol, Cay-14486), and serotonin (Cay-14332) in guinea pig ileum in a dose-dependent manner. Dapiprazole (0.05%, intracameral) reverses pupil dilation induced by a combination of the alpha1A-AR agonist phenylephrine and the muscarinic M4 antagonist tropicamide (Cay-16606) in rabbits. Formulations containing dapiprazole have been used in the treatment of iatrogenically induced mydriasis by adrenergic or parasympatholytic agents in certain eye examinations.Formal Name: 5,6,7,8-tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-1,2,4-triazolo[4,3-a]pyridine, monohydrochloride. CAS Number: 72822-13-0. Molecular Formula: C19H27N5 . HCl. Formula Weight: 361.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 3 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 236 nm. SMILES: CC(C=CC=C1)=C1N(CC2)CCN2CCC3=NN=C4N3CCCC4.Cl. InChi Code: InChI=1S/C19H27N5.ClH/c1-16-6-2-3-7-17(16)23-14-12-22(13-15-23)11-9-19-21-20-18-8-4-5-10-24(18)19,/h2-3,6-7H,4-5,8-15H2,1H3,1H. InChi Key: ZIODNPFQZIHCOE-UHFFFAOYSA-N.