Danicopan

Danicopan is an inhibitor of Factor D, a protease in the alternative complement pathway (APC, IC50 = 15 nM in a cell-free assay). It is selective for Factor D over a panel of 12 serine proteases when used at a concentration of 10 µM. Danicopan inhibits hemolysis of erythrocytes isolated from patients with paroxysmal nocturnal hemoglobinuria (IC50s = 4-27 nM). Danicopan (200 mg/kg, p.o.) suppresses APC activity in monkeys.Formal Name: (2S,4R)-1-[2-[3-acetyl-5-(2-methyl-5-pyrimidinyl)-1H-indazol-1-yl]acetyl]-N-(6-bromo-2-pyridinyl)-4-fluoro-2-pyrrolidinecarboxamide. CAS Number: 1903768-17-1. Synonyms: ACH-4471. Molecular Formula: C26H23BrFN7O3. Formula Weight: 580.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 249, 285 nm. SMILES: CC(C1=NN(CC(N2[C@@H](C[C@H](C2)F)C(NC3=CC=CC(Br)=N3)=O)=O)C4=CC=C(C5=CN=C(C)N=C5)C=C14)=O. InChi Code: InChI=1S/C26H23BrFN7O3/c1-14(36)25-19-8-16(17-10-29-15(2)30-11-17)6-7-20(19)35(33-25)13-24(37)34-12-18(28)9-21(34)26(38)32-23-5-3-4-22(27)31-23/h3-8,10-11,18,21H,9,12-13H2,1-2H3,(H,31,32,38)/t18-,21+/m1/s1. InChi Key: PIBARDGJJAGJAJ-NQIIRXRSSA-N.