Danicamtiv

Danicamtiv is a cardiac-specific myosin activator. It activates human cardiac S1 myosin when used at a concentration of 3 µM but does not activate skeletal or smooth muscle myosin. It increases sarcomere activity of isolated porcine left ventricular and atrial myofibrils with 50% active concentration values (AC50s) of 6 and 3.6 µM, respectively. Danicamtiv (3 µM) increases calcium sensitivity of isolated porcine skinned left ventricular and atrial fibers. Danicamtiv (2-3 mg/kg) also prolongs systolic ejection time and improves left ventricular ejection fraction and stroke volume in a dog model of heart failure.Formal Name: 4-[(1R)-1-[[3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl]sulfonyl]-1-fluoroethyl]-N-3-isoxazolyl-1-piperidinecarboxamide. CAS Number: 1970972-74-7. Synonyms: MYK-491, SAR440181. Molecular Formula: C16H20F3N5O4S. Formula Weight: 435.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: insol, PBS (pH 7.2): insol. SMILES: C[C@](F)(C1CCN(CC1)C(NC2=NOC=C2)=O)S(=O)(C3=CN(C)N=C3C(F)F)=O. InChi Code: InChI=1S/C16H20F3N5O4S/c1-16(19,29(26,27)11-9-23(2)21-13(11)14(17)18)10-3-6-24(7-4-10)15(25)20-12-5-8-28-22-12/h5,8-10,14H,3-4,6-7H2,1-2H3,(H,20,22,25)/t16-/m1/s1. InChi Key: NREKKBAMVWQRES-MRXNPFEDSA-N.