[D-Lys3]-GHRP-6 (trifluoroacetate salt)

[D-Lys3]-GHRP-6 is an antagonist of the growth hormone secretagogue receptor 1a (GHS-R1a, Ki = 4.25 nM). It inhibits ghrelin-induced cAMP accumulation in human aortic smooth muscle cells when used at a concentration of 20 nM. [D-Lys3]-GHRP-6 (12 mg/kg) decreases food intake in Zucker FA/FA lean and fa/fa obese rats.Formal Name: (R)-6-amino-2-((R)-2-((S)-2-amino-3-(1H-imidazol-5-yl)propanamido)-3-(1H-indol-3-yl)propanamido)-N-((S)-1-(((R)-1-(((S)-1,6-diamino-1-oxohexan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)hexanamide, trifluoroacetate salt. Synonyms: [D-Lys3]-Growth Hormone Releasing Peptide 6, His-D-Trp-D-Lys-Trp-D-Phe-Lys-NH2. Molecular Formula: C49H63N13O6 . XCF3COOH. Formula Weight: 930.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 2 mg/ml, DMSO: 2 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 218 nm. SMILES: OC(C(F)(F)F)=O.NCCCC[C@@H](C(N)=O)NC([C@@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](CCCCN)NC([C@H](NC([C@@H](N)CC2=CN=CN2)=O)CC3=CNC4=CC=CC=C34)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O. InChi Code: InChI=1S/C49H63N13O6.C2HF3O2/c50-20-10-8-18-39(44(53)63)58-47(66)41(22-30-12-2-1-3-13-30)61-49(68)43(24-32-27-56-38-17-7-5-15-35(32)38)62-46(65)40(19-9-11-21-51)59-48(67)42(23-31-26-55-37-16-6-4-14-34(31)37)60-45(64)36(52)25-33-28-54-29-57-33,3-2(4,5)1(6)7/h1-7,12-17,26-29,36,39-43,55-56H,8-11,18-25,50-52H2,(H2,53,63)(H,54,57)(H,58,66)(H,59,67)(H,60,64)(H,61,68)(H,62,65),(H,6,7)/t36-,39-,40+,41+,42+,43-,/m0./s1. InChi Key: FCNASYYZYRXDIS-CLEXWJBOSA-N.