D-Biotin

D-Biotin
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
CDX-B0148-G001 1 g -

3 - 9 Werktage*

54,00 €
CDX-B0148-G005 5 g -

3 - 9 Werktage*

147,00 €
CDX-B0148-G025 25 g -

3 - 9 Werktage*

605,00 €
 
White to off-white powder. Soluble in hot water or DMSO (49mg/ml at 25°C). D-(+)-Biotin, also... mehr
Produktinformationen "D-Biotin"
White to off-white powder. Soluble in hot water or DMSO (49mg/ml at 25°C). D-(+)-Biotin, also known as vitamin H or coenzyme R, is a water-soluble B-vitamin (vitamin B7). D-(+)-Biotin is a cofactor responsible for carbon dioxide transfer in five carboxylase enzymes, such as acetyl-CoA carboxylase alpha, acetyl-CoA carboxylase beta, methylcrotonyl-CoA carboxylase, propionyl-CoA carboxylase or pyruvate carboxylase. It is important in fatty acid synthesis, branched-chain amino acid catabolism and gluconeogenesis. It covalently attaches to the epsilon-amino group of specific lysine residues in these carboxylases. This biotinylation reaction requires ATP and is catalyzed by holocarboxylase synthetase. Biotin is also covalently attached to distinct lysine residues in histones, affecting chromatin structure and mediating gene regulation. Biotin is widely used throughout the biotechnology industry to conjugate proteins for biochemical assays. Biotin's small size means the biological activity of the protein will most likely be unaffected. This process is called biotinylation. Because both streptavidin and avidin bind biotin with high affinity (Kd of 10-14 mol/l to 10-15 mol/l) and specificity, biotinylated proteins of interest can be isolated from a sample by exploiting this highly stable interaction. The sample is incubated with streptavidin/avidin beads, allowing capture of the biotinylated protein of interest. The attachment of biotin to various chemical sites is used to study various processes, including protein localization, protein interactions, DNA transcription and replication.
Schlagworte: Bios II, Biotin, Coenzyme R, Vitamin B7, Vitamin H, NSC 63865, Factor S
Hersteller: Chemodex
Hersteller-Nr: B0148

Eigenschaften

Anwendung: Vitamin H, Streptavidin/avidin ligand
MW: 244,3 D
Formel: C10H16N2O3S
Reinheit: >98%
Format: Solid

Datenbank Information

CAS : 58-85-5| Finde Alternativen

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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