CZC-54252

CZC-54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50s = 1.28 and 1.85 nM for wild-type and G2019S mutant forms of LRRK2, respectively). It has been shown to protect against neuronal injury induced by Parkinson's disease-related LRRK2-G2019S mutant activity in primary human neurons with an EC50 value of 1 nM.Formal Name: N-[2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-methanesulfonamide. CAS Number: 1191911-27-9. Molecular Formula: C22H25ClN6O4S. Formula Weight: 505.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/mL, DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL, DMSO: 10 mg/mL. lambdamax: 282 nm. SMILES: COC1=CC(N2CCOCC2)=CC=C1NC3=NC=C(Cl)C(NC4=CC=CC=C4NS(C)(=O)=O)=N3. InChi Code: InChI=1S/C22H25ClN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27). InChi Key: CLGWUCNXOBLWFM-UHFFFAOYSA-N.