CYM2503

Description: CYM2503 is a positive allosteric modulator (PAM) of the GAL2 receptor that potentiates galanin-induced IP1 production in vitro. It has no affinity for the orthosteric galanin binding site of the receptor (as measured by its inability to displace iodinated galanin, or to induce IP1 accumulation on its own). Target: Neuropeptide Y Receptor. Smiles: Cc1cc(=O)[nH]c2cc(NC(=O)[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)[C@H](CC3CCCCC3)NC(=O)OCC3c4ccccc4-c4ccccc34)ccc12. References: Lu X , Roberts R , Xia R , et al. GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models[J]. Proc Natl Acad Sci U S A, 2010, 107(34):15229-15234.