CYM 50260

CYM 50260 is an agonist of sphingosine-1-phosphate receptor 4 (S1P4). It induces gene transcription in a reporter assay using U2OS cells expressing human S1P4 (EC50 = 45 nM). CYM 50260 (25 µM) inhibits collagen-induced increases in PDGF-AB secretion from, and phosphorylated heat shock protein 27 (Hsp27) levels in, isolated human platelets. It also inhibits collagen-induced increases in platelet aggregate size. InChI: InChI=1S/C14H11Cl3FNO2/c15-9-1-3-12(11(16)7-9)20-5-6-21-13-4-2-10(8-18)19-14(13)17/h1-4,7H,5-6,8H2 InChIKey: FHPOTBQOUBMMCI-UHFFFAOYSA-N SMILES: ClC1=CC(Cl)=C(OCCOC2=CC=C(CF)N=C2Cl)C=C1