CU-76

CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS, IC50 = 0.24 µM). It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 (IRF3, Cay-22811) in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases IFN-stimulatory DNA-induced production of IFN-beta in THP-1 cells when used at concentrations of 10, 30, and 100 µM.Formal Name: methyl 4-amino-6-((3,5-difluoro-4-iodophenyl)amino)-1,3,5-triazine-2-carboxylate. CAS Number: 2400954-58-5. Molecular Formula: C11H8F2IN5O2. Formula Weight: 407.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:5): 0.1 mg/ml. lambdamax: 264 nm. SMILES: IC1=C(F)C=C(NC2=NC(N)=NC(C(OC)=O)=N2)C=C1F. InChi Code: InChI=1S/C11H8F2IN5O2/c1-21-9(20)8-17-10(15)19-11(18-8)16-4-2-5(12)7(14)6(13)3-4/h2-3H,1H3,(H3,15,16,17,18,19). InChi Key: DATILFYUDSRBBK-UHFFFAOYSA-N.