Zu "K17834" wurden 64 Artikel gefunden!
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NEU
Recombinant cGAS Enzyme, Active, Human, Full-Length
Artikelnummer: BBL-2227
Active, full-length Human Cyclic GMP-AMP synthase enzyme, His-tagged protein expressed and purified from E.coli. The enzyme has been thoroughly validated with Transcreener cGAS Activity Assays. For specific activity, please refer to the Certificate of Analysis for each individual enzyme lot. Purity is >90% in a 20mM...
| Schlagworte: | CGAS, 2'3'-cGAMP synthase, Cyclic GMP-AMP synthase, Mab-21 domain-containing protein 1 |
| Anwendung: | HTS, drug discovery, enzyme assays |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
ab 500,00 €
NEU
Recombinant cGAS Enzyme, Active, Mouse, Full-Length
Artikelnummer: BBL-2239
Active, full-length Mouse Cyclic GMP-AMP synthase enzyme, His-tagged protein expressed and purified from E.coli. The enzyme has been thoroughly validated with Transcreener cGAS Activity Assays. For specific activity, please refer to the Certificate of Analysis for each individual enzyme lot. Purity is >79% in a 10mM...
| Schlagworte: | Cgas, 2'3'-cGAMP synthase, Cyclic GMP-AMP synthase, Mab-21 domain-containing protein 1 |
| Anwendung: | HTS, drug discovery, enzyme assays |
| Exprimiert in: | E.coli |
| Ursprungsart: | mouse |
ab 500,00 €
CGAS Protein, Mouse, Recombinant (His)
Artikelnummer: TGM-TMPH-04498-100ug
Description: CGAS Protein, Mouse, Recombinant (His) is expressed in E. coli. The accession number is Q8C6L5.
| Schlagworte: | cGAMP synthase,cGAS,m-cGAS , 2'3'-cGAMP synthase , Cgas , Mab-21 domain-containing protein 1 , Cyclic GMP-AMP synthase ,... |
| MW: | 65.1 kD |
ab 134,00 €
LipidLaunch(TM) SM-102 LNP (naked mole-rat cGAS)
Artikelnummer: Cay44929-5
An SM-102-based LNP solution for expressing naked mole-rat cGAS, composed of SM-102, cholesterol, 1,2-DSPC, and DMG-PEG(2000) at a molar ratio of 50:38.5:10:1.5 and encapsulating mRNA encoding His-tagged naked mole-rat cGAS, intended for the overexpression of His-tagged naked mole-rat cGAS in vitro and can be used...
| Anwendung: | SM-102-based LNP solution for expressing naked mole-rat cGAS |
694,00 €
LipidLaunch(TM) SM-102 LNP (human cGAS)
Artikelnummer: Cay44930-5
An SM-102-based LNP solution for expressing human cGAS, composed of SM-102, cholesterol, 1,2-DSPC, and DMG-PEG(2000) at a molar ratio of 50:38.5:10:1.5 and encapsulating mRNA encoding His-tagged human cGAS, intended for the overexpression of His-tagged human wild-type cGAS in vitro and can be used in a variety of...
| Anwendung: | SM-102-based LNP solution for expressing human cGAS |
694,00 €
2'3'-cGAMP (sodium salt)
Artikelnummer: Cay19887-500
2'3'-cGAMP is a second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA. It contains a non-canonical 2'5'-phosphodiester bond and binds tightly to the adapter protein STING (stimulator of interferon genes) with a Kd value of 3.79...
| Schlagworte: | 2'-3'-Cyclic GMP-AMP, Guanosine-Adenosine 2',3'-cyclic monophosphate, adenylyl-(3'->5')-2'-guanylic acid, cyclic... |
| Anwendung: | Second messenger |
| MW: | 718.4 D |
ab 305,00 €
cGAS (human, recombinant)
Artikelnummer: Cay22810-100
Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a nucleotidyltransferase located in the cytosol that acts as a cytosolic DNA sensor to detect foreign DNA from microbial pathogens as part of the innate immune response. Upon binding to cytosolic DNA, cGAS produces the cyclic dinucleotide second messenger cGAMP, which...
| Schlagworte: | cGAS, cGAS, h-cGAS, h-cGAS, cGAMP synthase, cGAMP synthase, 2'3'-cGAMP synthase, 2'3'-cGAMP synthase, Cyclic GMP-AMP... |
| Anwendung: | Cell based assays, ELISA, EPR/ESR, enzyme activity, FC, HTS, IF, IP, MS, Sample Preparation, WB |
| Exprimiert in: | E.coli |
941,00 €
CU-76
Artikelnummer: Cay31030-1
CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS, IC50 = 0.24 µM). It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 (IRF3, Cay-22811) in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases...
| Schlagworte: | methyl 4-amino-6-((3,5-difluoro-4-iodophenyl)amino)-1,3,5-triazine-2-carboxylate |
| Anwendung: | cGAS inhibitor |
| CAS | 2400954-58-5 |
| MW: | 407.1 D |
ab 126,00 €
G150
Artikelnummer: Cay28318-1
G150 is an inhibitor of cyclic GMP-AMP synthase (cGAS, IC50 = 10.2 nM for the human enzyme). It is selective for human cGAS over mouse cGAS (IC50 = 25,000 nM). G150 inhibits dsDNA-induced expression of IFNB1 in THP-1 cells and isolated human monocyte-derived macrophages (IC50s = 1.96 and 0.62 µM, respectively) but...
| Schlagworte: | 1-[9-(6-amino-3-pyridinyl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxy-ethanone |
| Anwendung: | cGAS inhibitor |
| CAS | 2369751-30-2 |
| MW: | 391.3 D |
ab 169,00 €
cGAS Inhibitor Screening Assay Kit
Artikelnummer: Cay701930-96
Cayman's cGAS Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of human cGAS, which is a cytosolic dsDNA sensor that detects microbial pathogens. The assay directly measures 2'3'-cGAMP produced by cGAS in the presence of DNA, ATP, and GTP. The cyclic...
| Schlagworte: | 2'3'-cGAMP Synthase, C6orf150, Cyclic GMP-AMP Synthase |
| Anwendung: | Competitive ELISA, cGAS inhibitor screening |
| Spezies-Reaktivität: | human |
943,00 €
CU-32
Artikelnummer: Cay31029-1
CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS, IC50 = 0.45 µM). It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 (IRF3, Cay-22811) in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also...
| Schlagworte: | methyl 4-amino-6-((4-iodophenyl)amino)-1,3,5-triazine-2-carboxylate |
| Anwendung: | cGAS inhibitor |
| CAS | 2400954-16-5 |
| MW: | 371.1 D |
ab 126,00 €
RU-521
Artikelnummer: Cay31765-5
RU-521 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS, IC50 = 0.11 µM). It inhibits dsDNA-, but not IFN-beta- or 5'ppp-HP20 RNA-, induced IFN-beta1-dependent gene expression in reporter assays and does not inhibit Pam3CSK4-, poly(I:C)-, or LPS-induced Il6 mRNA expression in RAW 264.7 cells, indicating...
| Schlagworte: | RU-320521, 3-[1-(6,7-dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-1(3H)-isobenzofuranone |
| Anwendung: | cGAS inhibitor |
| CAS | 2262452-06-0 |
| MW: | 415.2 D |
ab 58,00 €