CU-115

CU-115 is a toll-like receptor 8 (TLR8) antagonist (IC50 = 1.04 µM). It is selective for TLR8 over TLR7 (IC50 = >50 µM). CU-115 inhibits increases in type I IFN transcriptional activity induced by the ssRNA nucleic acid ligands 3p-hpRNA or G3-YSD in a luciferase reporter assay when used at concentrations of 5 and 20 µM. It decreases TNF-alpha and IL-1beta production induced by R-848 (Cay-14806) in THP-1 cells when used at a concentration of 5 µM.Formal Name: N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodo-benzamide. CAS Number: 2471982-20-2. Molecular Formula: C21H11F7INO2. Formula Weight: 569.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10mg/mL, DMSO: 10mg/mL, DMSO:PBS (pH 7.2) (1:5): 0.15mg/mL, Ethanol: 0.25mg/mL. SMILES: O=C(NC1=CC=C(OC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C=C1)C3=C(I)C=CC=C3F. InChi Code: InChI=1S/C21H11F7INO2/c22-16-2-1-3-17(29)18(16)19(31)30-13-4-6-14(7-5-13)32-15-9-11(20(23,24)25)8-12(10-15)21(26,27)28/h1-10H,(H,30,31). InChi Key: QYSLCRYVUJORPX-UHFFFAOYSA-N.