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Zu "K10170" wurden 68 Artikel gefunden!
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NEU
Artikelnummer: Cay37686-10
CL075 is a toll-like receptor 8 (TLR8) agonist. It induces NF-kappaB activation in a reporter assay using HEK293 cells expressing recombinant human TLR8 and TNF-alpha production in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 1 to 10 µM. In vivo, CL075 induces...
Schlagworte: | 3M-002, 2-propyl-thiazolo[4,5-c]quinolin-4-amine |
Anwendung: | TLR8 agonist |
CAS | 256922-53-9 |
MW: | 243.3 D |
ab 118,00 €
Artikelnummer: ELK-ELK2737.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TLR8. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TLR8. Next,...
Schlagworte: | CD288, Toll-like receptor 8 |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: ELK-EA186.100
Toll-like receptor 8 is a protein that in humans is encoded by the TLR8 gene. TLR8 has also been designated as CD288. Protein function: Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876, PubMed:32433612). Controls host immune response against pathogens through recognition of...
Schlagworte: | Anti-CD288, Anti-Toll-like receptor 8, TLR8 Rabbit pAb |
Anwendung: | IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
283,00 €
Artikelnummer: Cay14806-10
R-848 is an immune response modifier that mimics the pathogen-associated molecular patterns that activate immune cells through Toll-like receptor 7 (TLR7) and TLR8. It demonstrates potent anti-tumor and anti-viral properties and has been used to study the innate immune response to viral infections. At 1 µg/ml,...
Schlagworte: | Resiquimod, S 28463, 4-amino-2-(ethoxymethyl)-alpha,alpha-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol |
Anwendung: | Immune response modifier, TLR7 / TLR8 PAMP |
CAS | 144875-48-9 |
MW: | 314.4 D |
ab 66,00 €
Artikelnummer: Cay25349-1
CU-CPT8m is an antagonist of toll-like receptor 8 (TLR8, Kd = 220 nM, IC50 = 67 nM in a reporter assay). It is selective for TLR8 over a panel of all other human TLRs when used at a concentration of 1 µM. CU-CPT8m (1 µM) inhibits increases in TNF-alpha and IL-8 mRNA expression induced by the TLR8 agonist R-848...
Schlagworte: | 7-(3-methylphenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxamide |
Anwendung: | TLR8 antagonist |
CAS | 125079-83-6 |
MW: | 252.3 D |
ab 43,00 €
Artikelnummer: Cay13592-1
The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor...
Schlagworte: | TLR8 |
Anwendung: | WB, FC (intracellular, Cell surface), IHC (paraffin) |
Wirt: | Mouse |
Spezies-Reaktivität: | human |
432,00 €
Artikelnummer: 200-301-I30
Anti-TLR8 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-TLR8 from human and mouse based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-TLR8 from other sources has not been determined. Protein function: Key component of...
Schlagworte: | Anti-TLR8, Anti-CD288, Anti-Toll-like receptor 8 |
Anwendung: | FC, IHC, WB |
Wirt: | Mouse |
Spezies-Reaktivität: | human |
791,00 €
Artikelnummer: Cay22952-5
Motolimod is an agonist of toll-like receptor 8 (TLR8). It increases the production of TNF-alpha and IL-12 in human peripheral blood mononuclear cells (PBMCs, EC50s = 140 and 120 nM, respectively), monocytes, and myeloid dendritic cells. Motolimod also increases IFN-gamma production in natural killer (NK) cells and...
Schlagworte: | VTX-2337, 2-amino-N,N-dipropyl-8-[4-(1-pyrrolidinylcarbonyl)phenyl]-3H-1-benzazepine-4-carboxamide |
Anwendung: | Toll-like receptor 8 (TLR8) agonist |
CAS | 926927-61-9 |
MW: | 458.6 D |
ab 44,00 €
-15 %
Rabattaktion
Artikelnummer: ABE-10-3005-100
Toll like receptor 8, also known as CD288, is a member of TLR family. It plays an important role in sensing phagocytosed pathogen. TLR8 recognizes ssRNA and recruits MyD88 and leads to the activation of transcription factor NF-kappa B. TLR8 TLR8 has two splice variants, viz., TLR8v1 and TLR8v2 and one missense...
Schlagworte: | Anti-TLR8, Anti-CD288, Anti-Toll-like receptor 8, Monoclonal Antibody to TLR8/CD288 (Clone: ABM15F6) |
Anwendung: | IHC |
Wirt: | Mouse |
Spezies-Reaktivität: | human |
418,00 €
418,00 €
-15 %
Rabattaktion
Artikelnummer: ABE-10-3005-F-100
Toll like receptor 8, also known as CD288, is a member of TLR family. It plays an important role in sensing phagocytosed pathogen. TLR8 recognizes ssRNA and recruits MyD88 and leads to the activation of transcription factor NF-kappa B. TLR8 has two splice variants, viz., TLR8v1 and TLR8v2 and one missense variant,...
Schlagworte: | Anti-TLR8, Anti-CD288, Anti-Toll-like receptor 8, Monoclonal Antibody to TLR8/CD288 FITC Conjugated (Clone: ABM15F6) |
Anwendung: | FC |
Wirt: | Mouse |
Spezies-Reaktivität: | human |
158,00 €
ab 134,30 €
-15 %
Rabattaktion
Artikelnummer: ABE-10-3005-NALE-100
Toll like receptor 8, also known as CD288, is a member of TLR family. It plays an important role in sensing phagocytosed pathogen. TLR8 recognizes ssRNA and recruits MyD88 and leads to the activation of transcription factor NF-kappa B. TLR8 TLR8 has two splice variants, viz., TLR8v1 and TLR8v2 and one missense...
Schlagworte: | Anti-TLR8, Anti-CD288, Anti-Toll-like receptor 8, Monoclonal Antibody to TLR8/CD288 (Clone: ABM15F6) |
Anwendung: | IHC |
Wirt: | Mouse |
Spezies-Reaktivität: | human |
418,00 €
355,30 €
Artikelnummer: AG-20T-0307-C100
TLR8 (Toll-like Receptor 8) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR8 is a nucleotide-sensing TLR. TLR8 and TLR7 recognize single-stranded RNA (ssRNA) sequences containing GU-rich or poly-U sequences as their...
Schlagworte: | Anti-TLR8, Anti-CD288, Anti-Toll-like receptor 8 |
446,00 €