CTAP (trifluoroacetate salt)

CTAP is a water soluble, cyclic octapeptide which acts as a receptor antagonist that is selective for the µ opioid receptor (IC50 = 3.5 nM) over the delta receptor (IC50 = 4,500 nM). It is a poor antagonist of the somatostatin receptor (IC50 = 14.3 µM). CTAP is at least 10-fold more potent than naltrexone as an antagonist of diverse compounds which have antinociceptive effects through the µ opioid receptor. It resists enzymatic metabolism in the blood and enters the brain and cerebrospinal fluid.Formal Name: D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-arginyl-L-threonyl-3-mercapto-L-valyl-cyclic (2->7)-disulfide-L-threoninamide, trifluoroacetate salt. Molecular Formula: C51H69N13O11S2 . XCF3COOH. Formula Weight: 1104.3. Formulation: (Request formulation change), A solid. Solubility: Water: soluble. SMILES: O=C([C@@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CC3=CC=C(C=C3)O)NC([C@@H](NC([C@@H](CC4=CC=CC=C4)N)=O)CSSC(C)([C@H](NC5=O)C(N[C@@H]([C@@H](C)O)C(N)=O)=O)C)=O)=O)N[C@@H](CCCNC(N)=N)C(N[C@H]5[C@@H](C)O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C51H69N13O11S2.C2HF3O2/c1-26(65)39(42(53)68)62-49(75)41-51(3,4)77-76-25-38(61-43(69)33(52)21-28-11-6-5-7-12-28)47(73)59-36(22-29-16-18-31(67)19-17-29)45(71)60-37(23-30-24-57-34-14-9-8-13-32(30)34)46(72)58-35(15-10-20-56-50(54)55)44(70)63-40(27(2)66)48(74)64-41,3-2(4,5)1(6)7/h5-9,11-14,16-19,24,26-27,33,35-41,57,65-67H,10,15,20-23,25,52H2,1-4H3,(H2,53,68)(H,58,72)(H,59,73)(H,60,71)(H,61,69)(H,62,75)(H,63,70)(H,64,74)(H4,54,55,56),(H,6,7)/t26-,27-,33-,35+,36+,37-,38+,39+,40+,41-,/m1./s1. InChi Key: OCNOBNFWFKDFMD-XQGGKHMTSA-N.