CPSI-1306

CPSI-1306 is an inhibitor of macrophage inhibitory factor (MIF). In vivo, CPSI-1306 (20 mg/kg per day) decreases skin thickness and myeloperoxidase (MPO) activity and induces keratinocyte apoptosis, as well as reduces papilloma formation and progression to micro-invasive squamous cell carcinoma (SCC) in a mouse model of UVB-induced SCC. It lowers blood glucose levels and serum levels of IL-6 and TNF-alpha in a mouse model of non-insulin-dependent diabetes mellitus (NIDDM) induced by streptozotocin (Cay-13104).Formal Name: 2-[3-(2,4-difluorophenyl)-4,5-dihydro-5-isoxazolyl]-1-(4-morpholinyl)-ethanone. CAS Number: 1309793-47-2. Molecular Formula: C15H16F2N2O3. Formula Weight: 310.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml. lambdamax: 258 nm. SMILES: FC1=CC=C(C2=NOC(CC(N3CCOCC3)=O)C2)C(F)=C1. InChi Code: InChI=1S/C15H16F2N2O3/c16-10-1-2-12(13(17)7-10)14-8-11(22-18-14)9-15(20)19-3-5-21-6-4-19/h1-2,7,11H,3-6,8-9H2. InChi Key: GUWOSEVHCSNYFK-UHFFFAOYSA-N.