CP-547632

Description: CP-547632 is an orally available and potent, ATP-competitive dual inhibitor of VEGFR-2 and FGF kinase F with IC50s of 11 nM and 9 nM, respectively. CP-547632 is selective, with higher selectivity for VEGFR2 and bFGF than for EGFR, PDGFRbeta and related tyrosine kinases (TKs). PDGFRbeta and related tyrosine kinases (TKs) CP-547632 has antitumour activity. Target: FGFR, BTK, VEGFR, PDGFR. Smiles: NC(=O)c1c(NC(=O)NCCCCN2CCCC2)snc1OCc1c(F)cc(Br)cc1F. References: Beebe JS, et al. Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy. Cancer Res. 2003 Nov 1 , 63(21):7301-9.