Coumestrol

Coumestrol is a phytoestrogen that occurs naturally in soybeans, spinach, and clover. It competitively (vs. 17beta-estradiol, Cay-10006315) binds the estrogen receptors ERalpha (IC50 = 11 nM) and ERbeta (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells. Coumestrol is also a weak antagonist of pregnane X receptor (IC50 = 12 µM) as well as a potential inverse agonist of the constitutive androstane receptor (EC50 = 30 µM).Formal Name: 3,9-dihydroxy-6H-benzofuro[3,2-c][1]benzopyran-6-one. CAS Number: 479-13-0. Synonyms: NSC 22842. Molecular Formula: C15H8O5. Formula Weight: 268.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 25 mg/ml. lambdamax: 244, 305, 344 nm. SMILES: O=C1OC2=C(C=CC(O)=C2)C3=C1C4=CC=C(O)C=C4O3. InChi Code: InChI=1S/C15H8O5/c16-7-1-3-9-11(5-7)19-14-10-4-2-8(17)6-12(10)20-15(18)13(9)14/h1-6,16-17H. InChi Key: ZZIALNLLNHEQPJ-UHFFFAOYSA-N.