Coniferyl Alcohol

Coniferyl alcohol is a monolignol that has been found in pine sap. It is a precursor in the biosynthesis of lignin and has been used in the synthesis of lignin and a variety of phytochemicals. Coniferyl alcohol is an inhibitor of S-adenosyl-homocysteine hydrolase (SAAH) in vitro (IC50 = 34 nM). It increases the promoter activity of Hsp25 and Hsp70 in NCI H460 cells, as well as protein levels of Hsf1, Hsp27, and Hsp70 in L132 human lung fibroblast cells when used at a concentration of 3 µM. It also prevents cell death of Hsf1+/+, but not Hsf1-/-, mouse embryonic fibroblasts induced by paclitaxel (Cay-10461), cisplatin (Cay-13119), or ionizing radiation (IR), and inhibits IR-induced bone marrow damage in mice when administered at a dose of 10 mg/kg.Formal Name: 4-(3-hydroxy-1-propen-1-yl)-2-methoxy-phenol. CAS Number: 458-35-5. Synonyms: Coniferol. Molecular Formula: C10H12O3. Formula Weight: 180.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 25mg/mL, DMSO: 25mg/mL, Ethanol: 30mg/mL, PBS (pH 7.2): 0.3mg/mL. lambdamax: 266 nm. SMILES: OC1=C(OC)C=C(/C=C/CO)C=C1. InChi Code: InChI=1S/C10H12O3/c1-13-10-7-8(3-2-6-11)4-5-9(10)12/h2-5,7,11-12H,6H2,1H3/b3-2+. InChi Key: JMFRWRFFLBVWSI-NSCUHMNNSA-N. Origin: Synthetic.