CK2/ERK8-IN-1

Description: CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 µM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 µM, 11.9 µM, and 15.25 µM). Target: Casein Kinase, DYRK, ERK, Apoptosis, Pim. Smiles: CN(C)c1nc2c(Br)c(Br)c(Br)c(Br)c2n1CC(O)=O. References: Pagano MA, et al. The selectivity of inhibitors of protein kinase CK2: an update. Biochem J. 2008 Nov 1,415(3):353-65.