Cipargamin

Description: Cipargamin (NITD609) is an effective antimalarial compound. It has an IC50 of appr 1 nM against P. falciparum. Target: Parasite. Smiles: O=C1[C@]2(C3=C(C=4C(N3)=CC(Cl)=C(F)C4)C[C@H](C)N2)C=5C(N1)=CC=C(Cl)C5. References: Zhou Y, et al. Spiroindolone that inhibits PfATPase4 is a potent, cidal inhibitor of Toxoplasma gondii tachyzoites in vitro and in vivo. Antimicrob Agents Chemother. 2014,58(3):1789-92.