Cinanserin (hydrochloride)

Cinanserin is a serotonin (5-HT) receptor antagonist. It inhibits 5-HT-induced effects on isolated rat uterus but not guinea pig ileum. Cinanserin inhibits 5-HT-induced gross excitation, gastric mucosal erosion, and anaphylactoid edema in mice and rats. Cinanserin (12 and 36 mg/kg, i.p.) impairs acquisition of a running response in rats trained for food reward. It inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) 3C-like proteinase (3CLpro, IC50 = 5 µM) and reduces SARS-CoV viral RNA levels in infected BHK-Rep-1 cells (IC50s = 19-34 µM). It also inhibits viral replication of murine hepatitis virus (MHV) in CCL-9.1 murine liver epithelial cells (IC50 = 31.25 µg/ml).Formal Name: N-[2-[[3-(dimethylamino)propyl]thio]phenyl]-3-phenyl-2-propenamide, monohydrochloride. CAS Number: 54-84-2. Synonyms: SQ 10,643. Molecular Formula: C20H24N2OS . HCl. Formula Weight: 376.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: Soluble. SMILES: O=C(NC1=C(SCCCN(C)C)C=CC=C1)/C=C/C2=CC=CC=C2.Cl. InChi Code: InChI=1S/C20H24N2OS.ClH/c1-22(2)15-8-16-24-19-12-7-6-11-18(19)21-20(23)14-13-17-9-4-3-5-10-17,/h3-7,9-14H,8,15-16H2,1-2H3,(H,21,23),1H/b14-13+,. InChi Key: LXGJPDKYMJJWRB-IERUDJENSA-N.