Chromanol 293B

Chromanol 293B is a blocker of slowly activating delayed-rectifier K+ current (IKs) with an IC50 value of 6.89 µM in Xenopus oocytes expressing rat IKs channels. It is selective, having no activity at rat Kv1.1 or Kir2.1 channels at a concentration of 30 µM. Chromanol 293B increases the rate and extent of IKs in guinea pig ventricular cells in a dose-dependent manner. It also inhibits cystic fibrosis transmembrane conductance regulator (CTFR) Cl- currents (ICTFR) with an IC50 value of 19 µM in Xenopus oocytes expressing human CTFR.Formal Name: rel-N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide. CAS Number: 163163-23-3. Synonyms: Chromanol 239B. Molecular Formula: C15H20N2O4S. Formula Weight: 324.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 2 mg/ml. lambdamax: 252 nm. SMILES: CC1(C)[C@H](O)[C@@H](N(S(CC)(=O)=O)C)C2=C(C=CC(C#N)=C2)O1. InChi Code: InChI=1S/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14+/m0/s1. InChi Key: HVSJHHXUORMCGK-UONOGXRCSA-N.