CHMFL-FLT3-122

CHMFL-FLT3-122 is an inhibitor of FMS-related tyrosine kinase 3 (FLT3, IC50 = 40 nM). It is selective for FLT3 over Bruton's tyrosine kinase (BTK) and C-Kit (IC50s = 421 and 559 nM, respectively) and a panel of 468 additional kinases at 1 µM. CHMFL-FLT3-122 inhibits the growth of MV4-11, MOLM-13, and MOLM-14 acute myeloid leukemia (AML) cells containing FLT3 bearing an internal-tandem duplication (FLT3-ITD, GI50s = 22, 21, and 42 nM, respectively). In vivo, CHMFL-FLT3-122 (50 mg/kg) inhibits tumor growth in an MV4-11 mouse xenograft model.. Solulibility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml: DMSO: Slightly soluble: 0.1-1 mg/ml.