Zu "K05092" wurden 270 Artikel gefunden!
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FLT3 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-04106-100ug
Description: FLT3 Protein, Human, Recombinant (His) is expressed in Baculovirus Insect Cells with N-6xHis. The accession number is P36888.
| Schlagworte: | FLK2 , Fetal liver kinase-2 (FLK-2) , STK1 , FLT3 , Fms-like tyrosine kinase 3 (FLT-3) , Stem cell tyrosine kinase 1... |
| MW: | 48.5 kD |
ab 102,00 €
FLT3-IN-17
Artikelnummer: Cay45396-1
A dual inhibitor of FLT3D835Y and FAK, inhibits growth of HCT116, MDA-MB-231, and A375 cells (GI50s = 0.25, 0.46, and 0.49 µM, respectively). SMILES: CS(NC1=CC=CC(C2=CSC3=C2N=C(N=C3)NC(C=C4)=CC=C4N5CCNCC5)=C1)(=O)=O. InChi Code:...
| Schlagworte: | N-[3-[2-[[4-(1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]-methanesulfonamide |
| Anwendung: | FLT3(D835Y) / FAK dual inhibitor |
| CAS | 2758999-62-9 |
| MW: | 480.61 D |
ab 97,00 €
G-749
Artikelnummer: TGM-T2620-100mg
Description: G-749, a new-type FLT3 inhibitor, exhibits effective and sustained inhibition of the FLT3 wild type and mutants. Target: TAM Receptor, c-RET, Apoptosis, FLT, Aurora Kinase. Smiles: CN1CCC(CC1)Nc1nc(Nc2ccc(Oc3ccccc3)cc2)c2c(n1)c(Br)c[nH]c2=O. References: Lee HK, et al. Blood. 2014, 123(14), 2209-2219.
| Schlagworte: | Denfivontinib, G749 |
| Anwendung: | FLT3 inhibitor |
| CAS | 1457983-28-6 |
| MW: | 521.41 D |
ab 34,00 €
Quizartinib
Artikelnummer: Cay17986-1
Quizartinib is an inhibitor of FMS-related tyrosine kinase 3 (FLT3, Kd = 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases. It inhibits the proliferation of the human leukemia cell line MV4-11, which harbors a homozygous FLT3-ITD mutation, with an IC50 value of...
| Schlagworte: | AC220, N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-N'-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]-urea |
| Anwendung: | FLT3 inhibitor |
| CAS | 950769-58-1 |
| MW: | 560.7 D |
ab 45,00 €
Flt3, active human recombinant protein
Artikelnummer: BPS-40225
Active human Flt3 (GenBank Accession No. NM_004119), (a.a. 564-end) with N-terminal His tag, MW=54.2 kDa, expressed in a Baculovirus infected Sf9 cell expression system. Assay condition: The enzyme reaction was carried out for 1h at room temperature in a buffer containing 50 mM HEPES (pH7.5), 10 mM MgCl2, 1 mM EDTA,...
| Schlagworte: | FLT3, STK-1, CD135, FLK-2, FLT-3, EC=2.7.10.1, Fetal liver kinase-2, FL cytokine receptor, Fms-like tyrosine kinase 3,... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 54.2 kD |
566,00 €
7BIO
Artikelnummer: AG-MR-C0020-M010
Soluble in DMSO or ethanol. Stock solutions can be made up to 10 mM in DMSO. Anticancer compound. Caspase-independent, non-apoptotic cell death inducer. ATP-competitive Flt3 inhibitor. Necrosis inducer. Aurora B and C kinase inhibitor. DYRK1A and DYRK 2 (Dual-specificity tyrosine phosphorylation-regulated...
| Schlagworte: | 7-Bromoindirubin-3'-oxime |
| Anwendung: | Flt3 inhibitor |
| CAS | 916440-85-2 |
| MW: | 356,2 D |
ab 165,00 €
UNC2025
Artikelnummer: Cay16613-50
UNC2025 is a potent, orally bioavailable inhibitor of the tyrosine kinases Mer and Flt3 (IC50s = 0.74 and 0.80 nM, respectively). It less potently inhibits Axl and Tyro3 (IC50s = 14 and 17 nM, respectively) and a panel of related kinases. UNC2025 blocks colony formation of Mer- and Flt3-dependent tumor cell lines...
| Schlagworte: | trans-4-[2-(butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclohexanol |
| Anwendung: | Mer/FLT3 dual inhibitor |
| CAS | 1429881-91-3 |
| MW: | 476.7 D |
ab 116,00 €
AC-710
Artikelnummer: Cay29498-1
AC-710 is an inhibitor of PDGFR family kinases (IC50s = 7.7, 10.5, 2, and 1.2 nM for PDGFRbeta, CSF1R, FLT3, and c-Kit, respectively). It is greater than 30-fold selective for PDGFR family kinases over a panel of 386 kinases, as well as over a panel of five cytochrome P450 (CYP) enzymes (IC50s = >40 µM). AC-710 (30...
| Schlagworte: | N-[4-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy... |
| Anwendung: | PDGFR family kinase (c-Kit, FLT3, PDGFRbeta, CSF1R) inhibitor |
| CAS | 1351522-04-7 |
| MW: | 562.7 D |
ab 57,00 €
Lestaurtinib
Artikelnummer: Cay12094-10
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. A JAK2 gene fusion mutation, JAK2V617F, that causes unchecked activation of various growth factors and cytokines, has been linked to myeloproliferative...
| Schlagworte: | A 154475.0, CEP-701, KT 5555, SP 924,... |
| Anwendung: | JAK2 inhibitor |
| CAS | 111358-88-4 |
| MW: | 439.5 D |
ab 69,00 €
Gilteritinib
Artikelnummer: Cay21503-10
Gilteritinib is an inhibitor of FMS-related tyrosine kinase 3 (FLT3, IC50 = 5 nM for the wild-type enzyme). It inhibits mutant forms of FLT3, including FLT3 with the internal tandem duplication mutation (FLT3-ITD), FLT3-ITD expressing the F691L mutation, and FLT3 with various tyrosine kinase domain mutations...
| Schlagworte: | ASP2215,... |
| Anwendung: | FLT3 / AXL inhibitor |
| CAS | 1254053-43-4 |
| MW: | 552.7 D |
ab 51,00 €
Pacritinib
Artikelnummer: Cay16709-500
FMS-like tyrosine kinase 3 (FLT3) and Janus kinase 2 (JAK2) are tyrosine kinases that mediate cytokine signaling and are frequently mutated in cancers, particularly acute myeloid leukemia. Pacritinib is an inhibitor of both FLT3 and JAK2 (IC50s = 22 and 23 nM, respectively). It also blocks the activities of the FLT3...
| Schlagworte: | SB1518,... |
| Anwendung: | FLT3 / JAK2 inhibitor |
| CAS | 937272-79-2 |
| MW: | 472.6 D |
ab 69,00 €
FLT3 Inhibitor
Artikelnummer: Cay18462-10
Fms-like tyrosine kinase (FLT3) is a cell-surface receptor with important roles in stem cell development, hematopoiesis, and cancer. FLT3 Inhibitor is a cell-permeable, ATP-competitive inhibitor of FLT3 (IC50 = 27 nM) that blocks the proliferation of myelomonocytic leukemia MV4-11 cells (IC50 = 0.41 µM). It is...
| Schlagworte: | Fms-like Tyrosine Kinase Inhibitor, TCS 359,... |
| Anwendung: | CD135 inhibitor |
| CAS | 301305-73-7 |
| MW: | 360.4 D |
ab 97,00 €