Zu "K05092" wurden 253 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
FLT3 Ligand, Human
Artikelnummer: GSC-Z05309-100
Flt-3 Ligand, also known as FL, is an alpha -helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages.Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.
| Schlagworte: | FLT3, FL cytokine receptor, Fetal liver kinase-2, Fms-like tyrosine kinase 3, Stem cell tyrosine kinase 1, Receptor-type... |
| Ursprungsart: | human |
| MW: | 17.61 kD |
ab 457,00 €
![FLT3/Flk-2[Biotin], His & Avi, Human](https://www.biomol.com/media/image/5f/74/a3/GSC-Z04466-100_200x200.png "FLT3/Flk-2[Biotin], His & Avi, Human")
FLT3/Flk-2[Biotin], His & Avi, Human
Artikelnummer: GSC-Z04466-100
The Flt-3 (fms-like tyrosine kinase) receptor, also named Flk-2 (fetal liver kinase) and Stk-1(stem cell tyrosine kinase) is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the receptor for SCF and FMS, the receptor for M-CSF. Tyrosine-protein kinase that acts as cell-surface...
| Schlagworte: | FLT3, FL cytokine receptor, Fetal liver kinase-2, Fms-like tyrosine kinase 3, Stem cell tyrosine kinase 1, Receptor-type... |
| Ursprungsart: | human |
| MW: | 61.2 kD |
ab 887,00 €
FLT3 Ligand hFc Chimera, Human
Artikelnummer: GSC-Z05311-100
Flt-3 Ligand, also known as FL, is an alpha -helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages.Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.
| Schlagworte: | FLT3, FL cytokine receptor, Fetal liver kinase-2, Fms-like tyrosine kinase 3, Stem cell tyrosine kinase 1, Receptor-type... |
| Ursprungsart: | human |
| MW: | 44.8 kD |
ab 551,00 €
FLT3 Ligand, His, Human
Artikelnummer: GSC-Z05310-100
Flt-3 Ligand, also known as FL, is an alpha -helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages.Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.
| Schlagworte: | FLT3, FL cytokine receptor, Fetal liver kinase-2, Fms-like tyrosine kinase 3, Stem cell tyrosine kinase 1, Receptor-type... |
| Ursprungsart: | human |
| MW: | 19.1 kD |
ab 551,00 €
FLT3/Flk-2 hFc Chimera, Mouse
Artikelnummer: GSC-Z06125-100
Flt-3 Ligand, also known as FL, is an alpha -helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages.Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.
| Schlagworte: | Flt3, FL cytokine receptor, Fetal liver kinase 2, Fms-like tyrosine kinase 3, Tyrosine-protein kinase receptor flk-2,... |
| Ursprungsart: | mouse |
| MW: | 84.78 kD |
ab 524,00 €
CHMFL-FLT3-122
Artikelnummer: Cay43137-1
CHMFL-FLT3-122 is an inhibitor of FMS-related tyrosine kinase 3 (FLT3, IC50 = 40 nM). It is selective for FLT3 over Bruton's tyrosine kinase (BTK) and C-Kit (IC50s = 421 and 559 nM, respectively) and a panel of 468 additional kinases at 1 µM. CHMFL-FLT3-122 inhibits the growth of MV4-11, MOLM-13, and MOLM-14 acute...
| Schlagworte: | HYML-122, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-(dimethylamino)-ethanone |
| Anwendung: | FMS-related tyrosine kinase 3 (FLT3) inhibitor |
| CAS | 1839150-56-9 |
| MW: | 471.57 D |
ab 89,00 €
Quizartinib
Artikelnummer: Cay17986-1
Quizartinib is an inhibitor of FMS-related tyrosine kinase 3 (FLT3, Kd = 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases. It inhibits the proliferation of the human leukemia cell line MV4-11, which harbors a homozygous FLT3-ITD mutation, with an IC50 value of...
| Schlagworte: | AC220, N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-N'-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]-urea |
| Anwendung: | FLT3 inhibitor |
| CAS | 950769-58-1 |
| MW: | 560.7 D |
ab 44,00 €
Flt3, active human recombinant protein
Artikelnummer: BPS-40225
Active human Flt3 (GenBank Accession No. NM_004119), (a.a. 564-end) with N-terminal His tag, MW=54.2 kDa, expressed in a Baculovirus infected Sf9 cell expression system. Assay condition: The enzyme reaction was carried out for 1h at room temperature in a buffer containing 50 mM HEPES (pH7.5), 10 mM MgCl2, 1 mM EDTA,...
| Schlagworte: | FLT3, STK-1, CD135, FLK-2, FLT-3, EC=2.7.10.1, Fetal liver kinase-2, FL cytokine receptor, Fms-like tyrosine kinase 3,... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 54.2 kD |
566,00 €
7BIO
Artikelnummer: AG-MR-C0020-M010
Soluble in DMSO or ethanol. Stock solutions can be made up to 10 mM in DMSO. Anticancer compound. Caspase-independent, non-apoptotic cell death inducer. ATP-competitive Flt3 inhibitor. Necrosis inducer. Aurora B and C kinase inhibitor. DYRK1A and DYRK 2 (Dual-specificity tyrosine phosphorylation-regulated...
| Schlagworte: | 7-Bromoindirubin-3'-oxime |
| Anwendung: | Flt3 inhibitor |
| CAS | 916440-85-2 |
| MW: | 356,2 D |
ab 165,00 €
UNC2025
Artikelnummer: Cay16613-50
UNC2025 is a potent, orally bioavailable inhibitor of the tyrosine kinases Mer and Flt3 (IC50s = 0.74 and 0.80 nM, respectively). It less potently inhibits Axl and Tyro3 (IC50s = 14 and 17 nM, respectively) and a panel of related kinases. UNC2025 blocks colony formation of Mer- and Flt3-dependent tumor cell lines...
| Schlagworte: | trans-4-[2-(butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclohexanol |
| Anwendung: | Mer/FLT3 dual inhibitor |
| CAS | 1429881-91-3 |
| MW: | 476.7 D |
ab 112,00 €
AC-710
Artikelnummer: Cay29498-1
AC-710 is an inhibitor of PDGFR family kinases (IC50s = 7.7, 10.5, 2, and 1.2 nM for PDGFRbeta, CSF1R, FLT3, and c-Kit, respectively). It is greater than 30-fold selective for PDGFR family kinases over a panel of 386 kinases, as well as over a panel of five cytochrome P450 (CYP) enzymes (IC50s = >40 µM). AC-710 (30...
| Schlagworte: | N-[4-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy... |
| Anwendung: | PDGFR family kinase (c-Kit, FLT3, PDGFRbeta, CSF1R) inhibitor |
| CAS | 1351522-04-7 |
| MW: | 562.7 D |
ab 54,00 €
Lestaurtinib
Artikelnummer: Cay12094-10
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. A JAK2 gene fusion mutation, JAK2V617F, that causes unchecked activation of various growth factors and cytokines, has been linked to myeloproliferative...
| Schlagworte: | A 154475.0, CEP-701, KT 5555, SP 924,... |
| Anwendung: | JAK2 inhibitor |
| CAS | 111358-88-4 |
| MW: | 439.5 D |
ab 67,00 €