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Zu "K05092" wurden 190 Artikel gefunden!
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Artikelnummer: NSJ-RQ7227
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. This gene encodes a class III...
Schlagworte: | Anti-FLT3, Anti-STK-1, Anti-FLK-2, Anti-CD135, Anti-FLT-3, EC=2.7.10.1, Anti-Fetal liver kinase-2, Anti-FL cytokine... |
Anwendung: | WB, IHC (paraffin), Direct ELISA |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, rat |
755,00 €
Artikelnummer: ELK-ELK1421.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human Flt3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human Flt3. Next,...
Schlagworte: | FLT3, FLK-2, FLT-3, STK-1, CD135, EC=2.7.10.1, Fetal liver kinase-2, FL cytokine receptor, Fms-like tyrosine kinase 3,... |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: Cay37737-10
HM43239 is an inhibitor of wild-type (WT) and internal tandem duplication (ITD) mutant FMS-related tyrosine kinase 3 (FLT3, IC50s = 1.1 and 1.8 nM, respectively). It also inhibits VEGFR2 and spleen tyrosine kinase (Syk) by 100 and 95%, respectively, when used at a concentration of 100 nM. HM43239 inhibits the growth...
Schlagworte: | Tuspetinib,... |
Anwendung: | FLT3 inhibitor |
CAS | 2294874-49-8 |
MW: | 501.1 D |
ab 169,00 €
Artikelnummer: Cay18271-5
Colony stimulating factor 1 (CSF1) is a cytokine that is involved in the recruitment and activation of tissue macrophages. It exerts these effects by binding to its corresponding receptor tyrosine kinase, the cFMS/CSF1 receptor (CSF1R). Pexidartinib is a brain-penetrant inhibitor of CSF1R, as well as c-Kit and FLT3...
Schlagworte: | PLX3397, N-[5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine |
Anwendung: | KIT / CSF1R / FLT3 inhibitor |
CAS | 1029044-16-3 |
MW: | 417.8 D |
ab 84,00 €
Artikelnummer: Cay17986-1
Quizartinib is an inhibitor of FMS-related tyrosine kinase 3 (FLT3, Kd = 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases. It inhibits the proliferation of the human leukemia cell line MV4-11, which harbors a homozygous FLT3-ITD mutation, with an IC50 value of...
Schlagworte: | AC220, N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-N'-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]-urea |
Anwendung: | FLT3 inhibitor |
CAS | 950769-58-1 |
MW: | 560.7 D |
ab 39,00 €
Artikelnummer: BPS-40225
Active human Flt3 (GenBank Accession No. NM_004119), (a.a. 564-end) with N-terminal His tag, MW=54.2 kDa, expressed in a Baculovirus infected Sf9 cell expression system. Assay condition: The enzyme reaction was carried out for 1h at room temperature in a buffer containing 50 mM HEPES (pH7.5), 10 mM MgCl2, 1 mM EDTA,...
Schlagworte: | FLT3, STK-1, CD135, FLK-2, FLT-3, EC=2.7.10.1, Fetal liver kinase-2, FL cytokine receptor, Fms-like tyrosine kinase 3,... |
Anwendung: | Enzyme kinetics, inhibitor screening |
MW: | 54.2 kD |
555,00 €
Artikelnummer: AG-MR-C0020-M010
Soluble in DMSO or ethanol. Stock solutions can be made up to 10 mM in DMSO. Anticancer compound. Caspase-independent, non-apoptotic cell death inducer. ATP-competitive Flt3 inhibitor. Necrosis inducer. Aurora B and C kinase inhibitor. DYRK1A and DYRK 2 (Dual-specificity tyrosine phosphorylation-regulated...
Schlagworte: | 7-Bromoindirubin-3'-oxime |
Anwendung: | Flt3 inhibitor |
CAS | 916440-85-2 |
MW: | 356,2 D |
ab 165,00 €
Artikelnummer: Cay16613-50
UNC2025 is a potent, orally bioavailable inhibitor of the tyrosine kinases Mer and Flt3 (IC50s = 0.74 and 0.80 nM, respectively). It less potently inhibits Axl and Tyro3 (IC50s = 14 and 17 nM, respectively) and a panel of related kinases. UNC2025 blocks colony formation of Mer- and Flt3-dependent tumor cell lines...
Schlagworte: | trans-4-[2-(butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclohexanol |
Anwendung: | Mer/FLT3 dual inhibitor |
CAS | 1429881-91-3 |
MW: | 476.7 D |
ab 95,00 €
Artikelnummer: Cay29498-1
AC-710 is an inhibitor of PDGFR family kinases (IC50s = 7.7, 10.5, 2, and 1.2 nM for PDGFRbeta, CSF1R, FLT3, and c-Kit, respectively). It is greater than 30-fold selective for PDGFR family kinases over a panel of 386 kinases, as well as over a panel of five cytochrome P450 (CYP) enzymes (IC50s = >40 µM). AC-710 (30...
Schlagworte: | N-[4-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy... |
Anwendung: | PDGFR family kinase (c-Kit, FLT3, PDGFRbeta, CSF1R) inhibitor |
CAS | 1351522-04-7 |
MW: | 562.7 D |
ab 48,00 €
Artikelnummer: Cay12094-10
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. A JAK2 gene fusion mutation, JAK2V617F, that causes unchecked activation of various growth factors and cytokines, has been linked to myeloproliferative...
Schlagworte: | A 154475.0, CEP-701, KT 5555, SP 924,... |
Anwendung: | JAK2 inhibitor |
CAS | 111358-88-4 |
MW: | 439.5 D |
ab 60,00 €
Artikelnummer: Cay21503-10
Gilteritinib is an inhibitor of FMS-related tyrosine kinase 3 (FLT3, IC50 = 5 nM for the wild-type enzyme). It inhibits mutant forms of FLT3, including FLT3 with the internal tandem duplication mutation (FLT3-ITD), FLT3-ITD expressing the F691L mutation, and FLT3 with various tyrosine kinase domain mutations...
Schlagworte: | ASP2215,... |
Anwendung: | FLT3 / AXL inhibitor |
CAS | 1254053-43-4 |
MW: | 552.7 D |
ab 43,00 €
Artikelnummer: Cay16709-500
FMS-like tyrosine kinase 3 (FLT3) and Janus kinase 2 (JAK2) are tyrosine kinases that mediate cytokine signaling and are frequently mutated in cancers, particularly acute myeloid leukemia. Pacritinib is an inhibitor of both FLT3 and JAK2 (IC50s = 22 and 23 nM, respectively). It also blocks the activities of the FLT3...
Schlagworte: | SB1518,... |
Anwendung: | FLT3 / JAK2 inhibitor |
CAS | 937272-79-2 |
MW: | 472.6 D |
ab 60,00 €