CHM-1

CHM-1 is an inhibitor of tubulin polymerization (IC50 = 0.68 µM) with anticancer activity. It inhibits colchicine (Cay-9000760) tubulin binding by 39% when used at a concentration of 5 µM. CHM-1 inhibits the growth of K562, NCI H226, HCT116, OVCAR-3, RXF 393L, SK-MEL-5, SF-268, and SF-295 cancer cells (mean GI50 = 130 nM). It induces apoptosis in HA22T hepatocellular carcinoma cells in a concentration-dependent manner. CHM-1 (10 mg/kg) reduces tumor volume and increases survival in an HA22T mouse xenograft model.Formal Name: 6-(2-fluorophenyl)-1,3-dioxolo[4,5-g]quinolin-8(5H)-one. CAS Number: 154554-41-3. Synonyms: NSC 656158. Molecular Formula: C16H10FNO3. Formula Weight: 283.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 228, 256, 326 nm. SMILES: O=C(C=C(C1=C(F)C=CC=C1)N2)C3=C2C=C(OCO4)C4=C3. InChi Code: InChI=1S/C16H10FNO3/c17-11-4-2-1-3-9(11)12-6-14(19)10-5-15-16(21-8-20-15)7-13(10)18-12/h1-7H,8H2,(H,18,19). InChi Key: ZMYDAPJHGNEFGQ-UHFFFAOYSA-N.