Chlorpromazine (hydrochloride)

Chlorpromazine (CPZ) is a typical antipsychotic and an antagonist of dopamine D2, D3, and D4 receptors (Kis = 0.66, 0.84, and 1.2 nM, respectively) as well as the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 1.8 nM). It is also an antagonist of histamine H1, alpha1a-, alpha2b-, and alpha2C-adrenergic, and M3 muscarinic acetylcholine receptors (Kis = 6, 0.28, 27, 46, and 47 nM, respectively). CPZ (10 mg/kg per day) increases latency to find the platform in a repealed acquisition water maze task and decreases vertical activity and stereotypic movements in the open field test in rats. CPZ (0.3, 1, and 3 mg/kg, s.c.) also reduces emesis induced by cisplatin (Cay-13119) in dogs.Formal Name: 2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine, monohydrochloride. CAS Number: 69-09-0. Synonyms: CPZ. Molecular Formula: C17H19ClN2S . HCl. Formula Weight: 355.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 256, 308 nm. SMILES: ClC1=CC=C(SC(C=CC=C2)=C2N3CCCN(C)C)C3=C1.Cl. InChi Code: InChI=1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20,/h3-4,6-9,12H,5,10-11H2,1-2H3,1H. InChi Key: FBSMERQALIEGJT-UHFFFAOYSA-N.