CGP 42112

CGP 42112 is an angiotensin II type 2 (AT2) receptor agonist. It binds to AT2 receptors (Ki = 0.24 nM) and inhibits cGMP production and tyrosine hydroxylase activity in primary porcine adrenal medullary cells when used at concentrations ranging from 0.001 to 1 µM, effects that can be blocked by the AT2 receptor antagonist PD 123319 (Cay-16099).Formal Name: N-(3-pyridinylcarbonyl)-L-tyrosyl-N6-[N2-[(phenylmethoxy)carbonyl]-L-arginyl]-L-lysyl-L-histidyl-L-prolyl-L-isoleucine. CAS Number: 127060-75-7. Molecular Formula: C52H69N13O11. Formula Weight: 1052.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: OC(C=C1)=CC=C1C[C@H](NC(C2=CN=CC=C2)=O)C(N[C@@H](CCCCNC([C@H](CCCNC(N)=N)NC(OCC3=CC=CC=C3)=O)=O)C(N[C@@H](CC4=CN=CN4)C(N5[C@H](C(N[C@H](C(O)=O)[C@@H](C)CC)=O)CCC5)=O)=O)=O. InChi Code: InChI=1S/C52H69N13O11/c1-3-32(2)43(50(73)74)64-48(71)42-17-11-25-65(42)49(72)41(27-36-29-56-31-59-36)62-46(69)39(60-47(70)40(26-33-18-20-37(66)21-19-33)61-44(67)35-14-9-22-55-28-35)15-7-8-23-57-45(68)38(16-10-24-58-51(53)54)63-52(75)76-30-34-12-5-4-6-13-34/h4-6,9,12-14,18-22,28-29,31-32,38-43,66H,3,7-8,10-11,15-17,23-27,30H2,1-2H3,(H,56,59)(H,57,68)(H,60,70)(H,61,67)(H,62,69)(H,63,75)(H,64,71)(H,73,74)(H4,53,54,58)/t32-,38-,39-,40-,41-,42-,43-/m0/s1. InChi Key: UXGNARZDONUMMK-LRMQDCNJSA-N.