Ceftiofur (hydrochloride)

Ceftiofur is a broad-spectrum cephalosporin antibiotic. It is active against porcine isolates of A. pleuropneumoniae, P. multocida, S. typhimurium, S. cholerae-suis, E. coli, S. suis, and beta-hemolytic streptococci with MIC90 values of less than or equal to 2 µg/ml. Ceftiofur exhibits curative rates of 43, 88, and 100% in a lactating bovine model of intramammary S. uberis infection when administered via intramammary infusion at a dose of 125 mg per infected quarter for 2, 5, and 8 days, respectively. Formulations containing ceftiofur have been used in the veterinary treatment of bacterial infections.Formal Name: (6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[(2-furanylcarbonyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monohydrochloride. CAS Number: 103980-44-5. Synonyms: U-64279A, U-67279A. Molecular Formula: C19H17N5O7S3 . HCl. Formula Weight: 560.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml, DMSO: 20 mg/ml, Ethanol: 15 mg/ml. lambdamax: 288 nm. SMILES: OC(C1=C(CSC(C2=CC=CO2)=O)CS[C@@]([C@@H]3NC(/C(C4=CSC(N)=N4)=N\OC)=O)([H])N1C3=O)=O.Cl. InChi Code: InChI=1S/C19H17N5O7S3.ClH/c1-30-23-11(9-7-34-19(20)21-9)14(25)22-12-15(26)24-13(17(27)28)8(5-32-16(12)24)6-33-18(29)10-3-2-4-31-10,/h2-4,7,12,16H,5-6H2,1H3,(H2,20,21)(H,22,25)(H,27,28),1H/b23-11-,/t12-,16-,/m1./s1. InChi Key: KEQFDTJEEQKVLM-JUODUXDSSA-N.