CE3F4

Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). CE3F4 is an uncompetitive inhibitor of Epac1 activity toward its effector Rap1 in vitro (IC50 = 23 µM) and in cells.. It has no effect on PKA activity. CE3F4 blocks Epac1-induced autophagy in cardiomyocytes stimulated with isoprenaline and blocks the activation of transient receptor potential canonical (TRPC) channels by the Epac activator 8-pCPT.Formal Name: 5,7-dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde. CAS Number: 143703-25-7. Molecular Formula: C11H10Br2FNO. Formula Weight: 351.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 30 mg/mL, DMSO:PBS (pH 7.2) (1:10): 0.09 mg/mL, Ethanol: 5 mg/mL. lambdamax: 220, 294 nm. SMILES: O=C([H])N1C(C)CCC2=C(Br)C(F)=C(Br)C=C21. InChi Code: InChI=1S/C11H10Br2FNO/c1-6-2-3-7-9(15(6)5-16)4-8(12)11(14)10(7)13/h4-6H,2-3H2,1H3. InChi Key: ZZLQPWXVZCPUGC-UHFFFAOYSA-N.