Zu "K08014" wurden 23 Artikel gefunden!
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CE3F4
Artikelnummer: TGM-T12616L-10mg
Description: CE3F4 is a selective antagonist of exchange protein directly activated by cAMP (Epac1, IC50s of 10.7 µM and 66 µM for Epac1 and Epac2(B), respectively). Target: cAMP. Smiles: CC1CCc2c(Br)c(F)c(Br)cc2N1C=O. References: Courilleau D, et al. The (R)-enantiomer of CE3F4 is a preferential inhibitor of human...
| Anwendung: | Epac1 inhibitor |
| CAS | 143703-25-7 |
| MW: | 351.01 D |
ab 46,00 €
8-pCPT-2'-O-methyl Cyclic AMP
Artikelnummer: Cay17143-1
Exchange proteins activated by cAMP (Epacs) are guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-pCPT-2'-O-methyl Cyclic AMP (8-pCPT-2'-O-Me-cAMP) is an 8-(4-chlorophenylthio) analog of cAMP that activates Epacs (AC50 = 1.8 µM). It is a super-activator of Epacs in that it dissociates...
| Schlagworte: | 8-CPT-2Me-cAMP, 8-pCPT-cAMP, 8-pCPT-2'-O-Me-cAMP, 8-[(4-chlorophenyl)thio]-2'-O-methyl-adenosine cyclic 3',5'-(hydrogen... |
| Anwendung: | EPAC activator |
| CAS | 634207-53-7 |
| MW: | 507.8 D |
ab 155,00 €
CE3F4
Artikelnummer: Cay17767-5
Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). CE3F4 is an uncompetitive inhibitor of Epac1 activity toward its effector Rap1 in vitro (IC50 = 23 µM) and in cells.. It has no effect on PKA activity. CE3F4 blocks Epac1-induced autophagy in...
| Schlagworte: | 5,7-dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde |
| Anwendung: | Epac1 inhibitor |
| CAS | 143703-25-7 |
| MW: | 351 D |
ab 107,00 €
ESI-09
Artikelnummer: Cay19130-10
Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). ESI-09 is an inhibitor of Epac1 and Epac2 with IC50 values of 3.2 and 1.4 µM, respectively. It shows no activity against PKA at concentrations as high as 25 µM. ESI-09 has been shown to block Akt...
| Schlagworte: | alpha-[2-(3-chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-beta-oxo-3-isoxazolepropanenitrile |
| Anwendung: | Epac1 / Epac2 inhibitor |
| CAS | 263707-16-0 |
| MW: | 330.8 D |
ab 44,00 €
HJC0197
Artikelnummer: Cay19092-1
Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). HJC0197 is a cell-permeable inhibitor of Epac1 and Epac2 (IC50 = 5.9 µM for Epac2). It inhibits Epac1-mediated Rap1-GDP exchange activity at 25 µM, but has no effect on cAMP-induced type I and II PKA...
| Schlagworte: | 4-cyclopentyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo-5-pyrimidinecarbonitrile |
| Anwendung: | Cell-permeable Epac1 / Epac2 inhibitor |
| CAS | 1383539-73-8 |
| MW: | 339.5 D |
ab 52,00 €
Anti-Epac1 / RAPGEF3, clone AEOG-18
Artikelnummer: NSJ-RQ4808
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. The activation of RaP1 by cAMP is independent of PKA and is mediated by recently discovered family of guanine nucleotide exchange factors (GEFs) called cAMP-GEFs or Epacs. The Epac signaling therefore represents a novel mechanism for cAMP...
| Schlagworte: | Anti-CGEF1, Anti-EPAC 1, Anti-RAPGEF3, Anti-cAMP-GEFI, Anti-Rap guanine nucleotide exchange factor 3, Anti-Exchange factor... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
772,00 €
Anti-RAPGEF3
Artikelnummer: ATA-HPA040365.100
Protein function: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a...
| Schlagworte: | Anti-CGEF1, Anti-EPAC 1, Anti-RAPGEF3, Anti-cAMP-GEFI, Anti-Rap guanine nucleotide exchange factor 3, Anti-Exchange factor... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 320,00 €
Anti-RAPGEF3
Artikelnummer: ATA-HPA043518.100
Protein function: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a...
| Schlagworte: | Anti-CGEF1, Anti-EPAC 1, Anti-RAPGEF3, Anti-cAMP-GEFI, Anti-Rap guanine nucleotide exchange factor 3, Anti-Exchange factor... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 320,00 €
Anti-RAPGEF3 / Epac1
Artikelnummer: NSJ-RQ6703
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Rap guanine nucleotide exchange factor 3 also known as exchange factor directly activated by cAMP 1 (EPAC1) or cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI) is a protein that in humans is encoded by the RAPGEF3 gene. As the name suggests, EPAC...
| Schlagworte: | Anti-CGEF1, Anti-EPAC 1, Anti-RAPGEF3, Anti-cAMP-GEFI, Anti-Rap guanine nucleotide exchange factor 3, Anti-Exchange factor... |
| Anwendung: | WB, IHC (paraffin), IF, FC, Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, monkey |
772,00 €
RAPGEF3 (human), recombinant protein
Artikelnummer: ABS-PP-6456.20
| Schlagworte: | Rap guanine nucleotide exchange factor 3, Exchange factor directly activated by cAMP 1, Exchange protein directly... |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 18.5 kD |
ab 90,00 €
Anti-RAPGEF3 Recombinant
Artikelnummer: ABS-RC-5303.100
Protein function: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a...
| Schlagworte: | Anti-Rap guanine nucleotide exchange factor 3, Anti-Exchange factor directly activated by cAMP 1, Anti-Exchange protein... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 206,00 €
RAPGEF3 (Vector pUC, Accession No. BC040534)
Artikelnummer: CSB-CL019331HU.10
Length: 966 Sequence: atggtgttga gaaggatgca ccggccccga agctgctcct accagctgct gctggagcac cagcgtccga gctgcatcca ggggctgcgc tggacaccac tcaccaacag cgaggagtcc ctggatttca gcgagagcct ggagcaggcc tccacagagc gggtgctcag ggctgggagg cagctgcatc ggcatctgct ggccacctgc ccaaacctca tccgagaccg gaagtaccac cttaggctct atcggcagtg...
| Schlagworte: | Uncharacterized protein |
| Anwendung: | Molecular biology, clone |
| Spezies-Reaktivität: | human |
363,00 €