Cdk9 Inhibitor

A Cdk9 inhibitor (IC50 = 39 nM), selective for Cdk9 over Cdk1-7 (IC50s = >1,000 nM for all), inhibits PRRSV replication in PRRSV-infected primary porcine alveolar macrophages at 6 to 200 nM. Formulation: A solid. InChI: InChI=1S/C26H21N5O4S/c1-16-10-11-18(13-22(16)30-36(2,34)35)29-24-14-23(27-15-28-24)17-6-5-7-19(12-17)31-25(32)20-8-3-4-9-21(20)26(31)33/h3-15,30H,1-2H3,(H,27,28,29). InChIKey: CKUFOBCNTCLXJP-UHFFFAOYSA-N. SMILES: CC1=CC=C(NC2=NC=NC(C3=CC(N4C(C(C=CC=C5)=C5C4=O)=O)=CC=C3)=C2)C=C1NS(C)(=O)=O