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Zu "K02211" wurden 62 Artikel gefunden!
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Artikelnummer: CSB-EP005079MO.1
Organism: Mus musculus (Mouse). Source: E.coli. Expression Region: 1-372aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged and C-termina Myc-tagged. Target Protein Sequence: MAKQYDSVEC PFCDEVTKYE KLAKIGQGTF GEVFKAKHRQ TGQKVALKKV LMENEKEGFP ITALREIKIL QLLKHENVVN LIEICRTKAS PYNRCKGSIY LVFDFCEHDL...
Schlagworte: | Cdk9, EC=2.7.11.23, EC=2.7.11.22, Cyclin-dependent kinase 9, Cell division protein kinase 9, Recombinant Mouse... |
Anwendung: | Activity not tested |
Exprimiert in: | E.coli |
Ursprungsart: | mouse |
MW: | 50.2 kD |
ab 283,00 €
Artikelnummer: Cay40958-10
THAL-SNS-032 is a proteolysis-targeting chimera (PROTAC) containing the cyclin-dependent kinase 2 (Cdk2), Cdk7, and Cdk9 inhibitor SNS-032 (Cay-17904) linked to a cereblon (CRBN) binding moiety. It selectively induces degradation of Cdk9 over Cdk1, Cdk2, and Cdk7 in MOLT-4 cells when used at a concentration of 250...
Schlagworte: | 4-[[[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]amino]carbonyl]-N-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperid... |
Anwendung: | Cdk9 degradation driving PROTAC |
CAS | 2139287-33-3 |
MW: | 869 D |
ab 468,00 €
Artikelnummer: CSB-PA006435.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
Schlagworte: | Anti-phospho-C-2K, Anti-phospho-CDK9, Anti-phospho-CDC2L4, Anti-phospho-Cyclin-dependent kinase 9, Anti-phospho-Cell... |
Anwendung: | ELISA, WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
ab 106,00 €
Artikelnummer: CSB-PA217262.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: CDK9. Antigen Species: Human
Schlagworte: | Anti-C-2K, Anti-CDK9, Anti-CDC2L4, Anti-Cyclin-dependent kinase 9, Anti-Cell division protein kinase 9,... |
Anwendung: | ELISA, WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
ab 163,00 €
Artikelnummer: Cay39772-10
KB-0742 is an inhibitor of cyclin-dependent kinase 9 (Cdk9, IC50 = 6 nM). It is selective for Cdk9 over Cdk1-8 (IC50s = 397->10,000 nM) and Cdk12-19 (IC50s = 372->10,000 nM). KB-0742 (0.64-7.73 µM) induces cell cycle arrest at the G1 phase and apoptosis in BT-20, BT-549, MDA-MB-231, MT-3, and Hs 578T triple-negative...
Schlagworte: | (1S,3S)-N1-[5-(1-ethylpropyl)pyrazolo[1,5-a]pyrimidin-7-yl]-1,3-cyclopentanediamine, monohydrochloride |
Anwendung: | Cdk9 inhibitor |
MW: | 323.9 D |
ab 127,00 €
Artikelnummer: Cay39845-1
P276-00 is an inhibitor of cyclin-dependent kinase 9 (Cdk9), Cdk4, and Cdk1 (IC50s = 0.020, 0.063, and 0.079 µM, respectively). It is selective for these CDKs over Cdk2/cyclin E, Cdk2/cyclin A, Cdk6, and Cdk7 (IC50s = 2.54, 0.224, 0.396, and 2.87 µM, respectively), as well as a panel of eight other kinases. P276-00...
Schlagworte: | Riviciclib, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-4H-1-benzopyran-4-one,... |
Anwendung: | Cdk9 / Cdk4 / Cdk1 inhibitor |
CAS | 920113-03-7 |
MW: | 438.3 D |
ab 119,00 €
Artikelnummer: Cay10009197-5
Flavopiridol is an orally bioavailable inhibitor of cyclin dependent kinases (IC50s = ~100, ~100, ~100, and 300 nM for Cdk1, Cdk2, Cdk4, and Cdk7, respectively). It also inhibits TEFb, a complex composed of Cdk9 and cyclin T1, with a Ki value of 3 nM. Flavopiridol inhibits transcription of a CMV promoter in HeLa...
Schlagworte: | Alvocidib, HL 275, HMR 1275, L-868,275,... |
CAS | 131740-09-5 |
MW: | 438.3 D |
ab 66,00 €
Artikelnummer: Cay33306-1
AZD 4573 is an inhibitor of cyclin-dependent kinase 9 (Cdk9, IC50 = 14 nM). It is selective for Cdk9 over Cdk1, Cdk7, Cdk4/6, and Cdk2 (IC50s = 370, 1,100, 1,100, and >10,000 nM, respectively). AZD 4573 (100 nM) induces apoptosis in MV4-11 acute myeloid leukemia (AML) cells. In vivo, AZD 4573 (15 mg/kg every other...
Schlagworte: | (1S,3R)-3-(acetylamino)-N-[5-chloro-4-(5,6-dihydro-5,5-dimethyl-4H-pyrrolo[1,2-b]pyrazol-3-yl)-2-pyridinyl]-cyclohexanecar... |
Anwendung: | Cdk9 inhibitor |
CAS | 2057509-72-3 |
MW: | 429.9 D |
ab 77,00 €
Artikelnummer: BPS-79628-1
Cyclin-dependent kinase 9 (CDK9) is the catalytic subunit of the positive transcription elongation factor b (P-TEFb), which phosphorylates the C-terminal domain of RNA polymerase II, a key player in the production of mature RNA. The CDK9 Assay Kit is designed to measure CDK9/CyclinT activity for screening and...
Schlagworte: | C-2K, CDC2L4, Cyclin-dependent kinase 9, Cell division protein kinase 9, Serine/threonine-protein kinase PITALRE, Cell... |
Anwendung: | Enzyme kinetics, drug discovery, HTS |
Spezies-Reaktivität: | human |
ab 847,00 €
Artikelnummer: A303-492A
Protein function: Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD...
Schlagworte: | Anti-C-2K, Anti-CDK9, Anti-CDC2L4, EC=2.7.11.22, EC=2.7.11.23, Anti-Cyclin-dependent kinase 9, Anti-Cell division protein... |
Anwendung: | WB, IP |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 164,00 €
Artikelnummer: A303-493A-T
Protein function: Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD...
Schlagworte: | Anti-C-2K, Anti-CDK9, Anti-CDC2L4, EC=2.7.11.22, EC=2.7.11.23, Anti-Cyclin-dependent kinase 9, Anti-Cell division protein... |
Anwendung: | WB, IP, IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse |
ab 164,00 €
Artikelnummer: Cay10011247-5
Cyclin-dependent kinases (CDKs) play a key role in regulating cell division by phosphorylating distinct substrates in different phases of the cell cycle. Cell cycle deregulation in many cancers often results from altered CDK activity. Thus, CDKs are potential pharmacological targets for anticancer agents. CAY10574...
Schlagworte: | 4-[(3,5-diamino-1H-pyrazol-4-yl)azo]-phenol |
Anwendung: | CDK9 inhibitor |
CAS | 140651-18-9 |
MW: | 218.2 D |
ab 34,00 €