CCT369260

CCT369260 is a degrader of Bcl-6. It induces degradation of Bcl-6 in SU-DHL-4, OCI-LY1, and Karpas-422 cells with half-maximal degradation concentration (DC50) values of 0.09, 0.049, and 0.062 µM, respectively. CCT369260 inhibits the growth of SU-DHL-4, OCI-LY1, and OCI-Ly3 cancer cells (GI50s = 0.092, 0.035, and 1.6 µM, respectively). It reduces intratumoral Bcl-6 levels in an OCI-LY1 lymphoma mouse xenograft model for up to ten hours after administration of a 15 mg/kg dose.Formal Name: rel-5-[[5-chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-2H-benzimidazol-2-one. CAS Number: 2253878-44-1. Molecular Formula: C24H31ClF2N6O2. Formula Weight: 509.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly Soluble: 1-10 mg/ml. SMILES: C[C@@H]1CN(C(N=C2NC(C=C3N4CCC(C)(C)O)=CC=C3N(C)C4=O)=NC=C2Cl)C[C@H](C)C1(F)F. InChi Code: InChI=1S/C24H31ClF2N6O2/c1-14-12-32(13-15(2)24(14,26)27)21-28-11-17(25)20(30-21)29-16-6-7-18-19(10-16)33(22(34)31(18)5)9-8-23(3,4)35/h6-7,10-11,14-15,35H,8-9,12-13H2,1-5H3,(H,28,29,30)/t14-,15+. InChi Key: VFNPUAOAEFMXQI-GASCZTMLSA-N.