CC-90011

CC-90011 is an inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 0. nM). It is selective for LSD1 over LSD2, monoamine oxidase A (MAO-A), and MAO-B at 10 µM. CC-90011 induces differentiation in THP-1 cells (EC50 = 7 nM) and inhibits the proliferation of NCI H1417 small cell lung cancer (SCLC) cells (EC50 = 6 nM). It also inhibits lipid accumulation induced by palmitic acid (Cay10006627) and oleic acid (Cay90260, Cay24659) in Huh7 hepatocytes when used at a concentration of 20 µM. In vivo, CC-90011 (2.5 mg/kg) reduces tumor volume in an NCI H1417 mouse xenograft model. SMILES N#CC1=CC=C(C(N=C(N2CCC(CC2)N)N3C)=C(C4=CC(F)=C(OC)C=C4)C3=O)C=C1F.O=S(O)(C5=CC=CC=C5)=O InChi Code InChI=1S/C24H23F2N5O2.C6H6O3S/c1-30-23(32)21(14-5-6-20(33-2)19(26)11-14)22(15-3-4-16(13-27)18(25)12-15)29-24(30)31-9-7-17(28)8-10-31,7-10(8,9)6-4-2-1-3-5-6/h3-6,11-12,17H,7-10,28H2,1-2H3,1-5H,(H,7,8,9) InChi Key AWZCBGWZNHQCIZ-UHFFFAOYSA-N