CB-65

CB-65 is a cannabinoid 2 (CB2) receptor inverse agonist. It selectively binds to CB2 over CB1 receptors (Kis = 3. nM and >1,000 nM, respectively) and increases forskolin-induced cAMP production in CHO cells expressing the human CB2 receptor (EC50 = 1. nM). CB-65 (0. 2. and 20 nM) inhibits HepG2 hepatocellular carcinoma (HCC) cell invasion in vitro.. Solulibility: DMSO: Sparingly soluble: 1-10 mg/ml: .