CAY10727

Description: CAY10727 is an inhibitor of protein arginine deiminase 3 (PAD3, kinact/KI= 15,600 M-1min-1).1It is selective for PAD3 over PAD1, -2, and -4 (kinact/KIs = 360, 1,110, and 1,460 M-1min-1, respectively). Target: Others. Smiles: ClC1=C(C2=CC(CN3C(=O)C(CCCNC(CCl)=N)NC3=O)=CC=C2)C=CC=C1. References: Jamali, H., Khan, H.A., Stringer, J.R., et al.Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment methodJ. Am. Chem. Soc.137(10)3616-3621(2015)