CAY10622

Two Rho-associated kinases (ROCK), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. CAY10622 is a potent, ureidobenzamide inhibitor of ROCK1 and ROCK2 with IC50 values of 6 and 4 nM, respectively. It is inactive (showing greater then 100-fold selectivity) against an additional 44 kinases.Formal Name: 3-[[[[[4-(aminocarbonyl)phenyl]amino]carbonyl]amino]methyl]-N-(1,2,3,4-tetrahydro-7-isoquinolinyl)-benzamide. CAS Number: 1038549-25-5. Molecular Formula: C25H25N5O3. Formula Weight: 443.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.15 mg/ml. lambdamax: 272 nm. SMILES: NC(C1=CC=C(NC(NCC2=CC(C(NC3=CC(CNCC4)=C4C=C3)=O)=CC=C2)=O)C=C1)=O. InChi Code: InChI=1S/C25H25N5O3/c26-23(31)18-5-7-21(8-6-18)30-25(33)28-14-16-2-1-3-19(12-16)24(32)29-22-9-4-17-10-11-27-15-20(17)13-22/h1-9,12-13,27H,10-11,14-15H2,(H2,26,31)(H,29,32)(H2,28,30,33). InChi Key: SCIFUGGHOXNSJC-UHFFFAOYSA-N.