Zu "K04514" wurden 95 Artikel gefunden!
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Anti-ROCK1 / Rho associated coiled coil containing...
Artikelnummer: NSJ-FY13332
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. ROCK1 antibody detects Rho associated coiled coil containing protein kinase 1, encoded by the ROCK1 gene. Rho associated coiled coil containing protein kinase 1 is a serine-threonine kinase that...
| Schlagworte: | Anti-ROCK1, Anti-p160 ROCK-1, Anti-Rho-associated protein kinase 1, Anti-Renal carcinoma antigen NY-REN-35,... |
| Anwendung: | WB, IHC, IP, FC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Anti-Recombinant ROCK1, clone 12B7
Artikelnummer: E-AN301001L.100
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound...
| Schlagworte: | Anti-ROCK1, Anti-p160 ROCK-1, Anti-Rho-associated protein kinase 1, Anti-Renal carcinoma antigen NY-REN-35,... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Y-27632 . dihydrochloride
Artikelnummer: AG-CR1-3564-M010
Potent, cell permeable, selective and ATP-competitive Rho-associated protein kinases inhibitor, including p160ROCK, ROCK-II and PRK2 inhibitor. Tumor cell invasion and metastasis suppressor. Smooth muscle relaxant. Decreases liver fibrosis by hepatic stellate cell growth inhibition. Antinociceptive. Blocks...
| Schlagworte: | Y-27632 - 2HCL, (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride |
| Anwendung: | ROCK kinase inhibitor |
| CAS | 129830-38-2 |
| MW: | 320.2 D |
ab 55,00 €
Y27632 dihydrochloride
Artikelnummer: LKT-Y1000.1
Y27632 is a selective inhibitor of Rho-associated protein kinase (ROCK), Y27632 binds to the catalytic site of ROCK, preventing binding of Ras-related GTPase Rho A, which is involved in actin cytoskeleton reorganization, cell adhesion, and cell migration. Y27632 inhibits downstream endothelin and TGF- -related...
| Anwendung: | ROCK inhibitor |
| CAS | 129830-38-2 |
| MW: | 320.26 D |
ab 128,00 €
Verosudil
Artikelnummer: Cay42234-10
A ROCK1 and ROCK2 inhibitor (Ki = 2 nM for both), selective for ROCK1 and ROCK2 over PKA, PKCtheta, MRCKalpha, and CaMKIV (Kis = 69, 9,332, 28, and 5,855 nM, respectively), decreases focal adhesion points on, and actin fiber length in, primary PTM cells at 1 µM, inhibits TGF-beta-induced increases in alpha-SMA...
| Schlagworte: | AR-12286, N-(1,2-dihydro-1-oxo-6-isoquinolinyl)-a-(dimethylamino)-3-thiopheneacetamide |
| Anwendung: | ROCK1 / ROCK2 inhibitor |
| CAS | 1414854-42-4 |
| MW: | 327.4 D |
ab 97,00 €
(S)-H-1152 (hydrochloride)
Artikelnummer: Cay10007653-1
Rho-associated kinase (ROCK), activated by GTP-linked Rho, phosphorylates targets that are involved in cytoskeletal remodeling, smooth muscle contraction, and neuronal development. H-1152 is a potent, specific, ATP-competitive, and cell permeable inhibitor of ROCK (Ki = 1.6 nM). It is a more potent inhibitor of ROCK...
| Schlagworte: | 5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methyl-isoquinoline, dihydrochloride |
| Anwendung: | ROCK inhibition |
| CAS | 451462-58-1 |
| MW: | 392.3 D |
ab 54,00 €
Fasudil hydrochloride
Artikelnummer: LKT-F0275.100
A potent Rho-kinase inhibitor and vasodilator. Since it was discovered, it has been used for the treatment of cerebral vasospasm, which is often due to subarachnoid hemorrhage, as well as to improve the cognitive decline seen in stroke victims. It has been found to be effective for the treatment of pulmonary...
| Anwendung: | ROCK inhibitor |
| CAS | 105628-07-7 |
ab 227,00 €
Y-27632-d4 (hydrochloride hydrate)
Artikelnummer: Cay42454-1
Y-27632-d4 is intended for use as an internal standard for the quantification of Y-27632 (Cay-10005583) by GC- or LC-MS. Y-27632 is an inhibitor of Rho-associated kinase 1 (ROCK1) and ROCK2 (Kis = 0. and 0. µM, respectively). It is selective for ROCK1 and ROCK2 over citron Rho-interacting kinase (CRIK),...
| Schlagworte: | trans-4-[(1R)-1-aminoethyl]-N-4-pyridinyl-d4-cyclohexanecarboxamide, dihydrochloride hyrdrate |
| Anwendung: | GC-MS, LC-MS, internal standard, quantification, ROCK1/ROCK2 inhibitor |
| MW: | 342.3 D |
409,00 €
Thiazovivin
Artikelnummer: Cay14245-1
Rho-associated kinase (ROCK) is a serine-threonine kinase known to play an important role in Rho-mediated cytoskeleton remodeling and contractile force generation. Down-regulation of ROCK signaling has been shown to enable the cell-adhesion interactions necessary for maintaining human embryonic stem cell survival...
| Schlagworte: | Tzv, N-(phenylmethyl)-2-(4-pyrimidinylamino)-4-thiazolecarboxamide |
| Anwendung: | Cell-permeable ROCK inhibitor |
| CAS | 1226056-71-8 |
| MW: | 311.4 D |
ab 64,00 €
H1152
Artikelnummer: SYN-1221-M001
Solid. Soluble in DMSO. H-1152 is a potent, specific, ATP-competitive and cell permeable ROCK inhibitor, with an IC50 of 12nM for ROCKII. H-1152 poorly inhibits PKA, PKC and myosin light chain kinase. Rho kinase (ROCK) activated by GTP-linked Rho phosphorylates targets that are involved in cytoskeletal remodelling,...
| Schlagworte: | (S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline dihydrochloride, H1152 |
| Anwendung: | Cell-permeable ROCK inhibitor |
| CAS | 871543-07-6 |
| MW: | 392,3 D |
ab 123,00 €
Y-27632 dihydrochloride
Artikelnummer: TGM-T1725-10mg
Description: Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells. Target: Apoptosis, ROCK. Smiles: Cl.Cl.C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1....
| Schlagworte: | Y-27632 2HCl |
| Anwendung: | ROCK kinase inhibitor |
| CAS | 129830-38-2 |
| MW: | 320.26 D |
ab 32,00 €
Y-27632
Artikelnummer: TGM-T1870-100mg
Description: Y-27632 is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells. Target: Apoptosis, ROCK. Smiles: C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1. References: Wu Y, et al. ROCK inhibitor Y27632...
| Anwendung: | Rho kinase (ROCK) inhibitor |
| CAS | 146986-50-7 |
| MW: | 247.34 D |
ab 32,00 €