CAY10452

Inhibitors of cyclooxygenase (COX) are generally grouped according to selectivity for COX-1 versus COX-2. However, many COX inhibitors also show an antitumor, pro-apoptotic activity that is distinct from COX inhibition - celecoxib is an example. CAY10452 is a celecoxib analog that retains potent, selective COX-2 inhibitory activity (IC50 = 32 nM), but does not induce apoptosis in prostate cancer cell lines even at 100 µM. CAY10452 is thus a clean, selective tool for the inhibition of COX-2.Formal Name: 4-[5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide. CAS Number: 170569-87-6. Synonyms: PTPBS. Molecular Formula: C16H12F3N3O2S. Formula Weight: 367.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:8): 0.1 mg/ml. lambdamax: 203, 253 nm. SMILES: FC(F)(F)C1=NN(C2=CC=C(S(=O)(N)=O)C=C2)C(C3=CC=CC=C3)=C1. InChi Code: InChI=1S/C16H12F3N3O2S/c17-16(18,19)15-10-14(11-4-2-1-3-5-11)22(21-15)12-6-8-13(9-7-12)25(20,23)24/h1-10H,(H2,20,23,24). InChi Key: MQPLMBSDWYIIID-UHFFFAOYSA-N.