CAY10404

CAY10404 is an inhibitor of COX-2 (IC50 = 50 = >500 µM). CAY10404 inhibits the proliferation of SH-EP and SH-SY5Y neuroblastoma cells (IC50s = ~60 µM for both), and induces apoptosis and cell cycle arrest at the G2/M phase in the same cells. It inhibits carrageenan-induced paw edema in rats when administered at a dose of 10 mg/kg.Formal Name: 3-[4-(methylsulfonyl)phenyl]-4-phenyl-5-(trifluoromethyl)-isoxazole. CAS Number: 340267-36-9. Molecular Formula: C17H12F3NO3S. Formula Weight: 367.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 21 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 17 mg/ml, Ethanol: 17 mg/ml. lambdamax: 239 nm. SMILES: FC(F)(F)c1onc(c2ccc(cc2)S(=O)(=O)C)c1c1ccccc1. InChi Code: InChI=1S/C17H12F3NO3S/c1-25(22,23)13-9-7-12(8-10-13)15-14(11-5-3-2-4-6-11)16(24-21-15)17(18,19)20/h2-10H,1H3. InChi Key: KKBWWVXRKULXHF-UHFFFAOYSA-N.