CAY10397

Prostaglandins are rapidly inactivated in vivo by the action of 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH). This enzyme oxidizes the 15-hydroxyl group and hydrogenates the 13,14-double bond, producing 13,14-dihydro-15 keto metabolites with greatly reduced biological activity. CAY10397 is a selective inhibitor of 15-hydroxy PGDH with an IC50 of approximately 10 µM. CAY10397 acts to prolong the lifetime and activity of endogenously produced prostaglandins both in cell culture and in vivo.Formal Name: 5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid. CAS Number: 78028-01-0. Synonyms: CK47A. Molecular Formula: C17H16N2O5. Formula Weight: 328.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: 0.1 M Na2CO3: 200 µg/ml, DMF: 35 mg/ml, DMSO: 25 mg/ml, Ethanol: 10 mg/ml. lambdamax: 261, 370 nm. SMILES: OC1=C(CC(O)=O)C=C(N=NC2=CC=C(C(OCC)=O)C=C2)C=C1. InChi Code: InChI=1S/C17H16N2O5/c1-2-24-17(23)11-3-5-13(6-4-11)18-19-14-7-8-15(20)12(9-14)10-16(21)22/h3-9,20H,2,10H2,1H3,(H,21,22). InChi Key: YYBSDOZYJSGLTH-UHFFFAOYSA-N.