Cariprazine

Description: Cariprazine (RGH-188) is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM). Target: Dopamine Receptor, 5-HT Receptor. Smiles: CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(Cl)c2Cl)CC1. References: Zimnisky R,etal.Cariprazine, a dopamine D(3)-receptor-preferring partial agonist, blocks phencyclidine-induced impairments of working memory, attention set-shifting, and recognition memory in the mouse.Psychopharmacology (Berl). 2013 Mar,226(1):91-100.