Carbenoxolone

Description: Carbenoxolone (Biogastrone) is an inhibitor of 11beta-HSD and gap junction connexin channels. Carbenoxolone inhibits macrophage migration into atria and prevents the development of fatty liver disease. Target: Dehydrogenase, Gap Junction Protein. Smiles: CC(C)([C@H](CC[C@@]1(C)[C@](C)(CC[C@@](C)(CC2)[C@H]3C[C@@]2(C)C(O)=O)C3=C2)[C@](C)(CC3)[C@H]1C2=O)[C@H]3OC(CCC(O)=O)=O. References: Azarashvili T, et al. Carbenoxolone induces permeability transition pore opening in rat mitochondria via the translocator protein TSPO and connexin43. Arch Biochem Biophys. 2014 Sep 15,558:87-94.