Capsanthin

Capsanthin is a carotenoid that has been found in C. annuum and has diverse biological activities. It reduces hydrogen peroxide-induced production of reactive oxygen species (ROS) and phosphorylation of ERK and p38 and prevents hydrogen peroxide-induced inhibition of gap junction intercellular communication in WB-F344 rat liver epithelial cells. Capsanthin (0.2 mg/animal) reduces the number of colonic aberrant crypt foci and preneoplastic lesions in a rat model of N-methylnitrosourea-induced colon carcinogenesis. It also reduces ear edema in a mouse model of inflammation induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014).Formal Name: (3R,3'S,5'R)-3,3'-dihydroxy-beta,kappa-caroten-6'-one. CAS Number: 465-42-9. Synonyms: all-trans-Capsanthin. Molecular Formula: C40H56O3. Formula Weight: 584.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: miscible, DMSO: miscible, Ethanol: miscible, PBS (pH 7.2): soluble. lambdamax: 472 nm. SMILES: CC(/C=C/C1=C(C)C[C@@H](O)CC1(C)C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(C)\C=C\C([C@@]2(C)C(C)(C)C[C@H](O)C2)=O. InChi Code: InChI=1S/C40H56O3/c1-29(17-13-19-31(3)21-23-36-33(5)25-34(41)26-38(36,6)7)15-11-12-16-30(2)18-14-20-32(4)22-24-37(43)40(10)28-35(42)27-39(40,8)9/h11-24,34-35,41-42H,25-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+/t34-,35+,40+/m1/s1. InChi Key: VYIRVAXUEZSDNC-RDJLEWNRSA-N. Origin: Plant/Capsicum annuum.