Caffeic Acid Phenethyl Ester

Description: Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective and immunomodulating activities. CAPE is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha and subsequent induction of heme oxygenase-1 (HO-1). Target: NF-kappaB, Apoptosis. Smiles: Oc1ccc(\C=C\C(=O)OCCc2ccccc2)cc1O. References: Natarajan K, et al. Proc Natl Acad Sci U S A. 1996, 93(17), 9090-9095.