Caerulomycin A

Caerulomycin A is an fungal metabolite originally isolated from Actinoalloteichus with antifungal and immunosuppressant activites. It inhibits the growth of C. albicans, C. glabrata, and C. krusei (MICs = 0.78-1.56, 0.39-0.78, and 0.78-1.56 µg/ml, respectively). Caerulomycin A induces expansion of CD4+Foxp3+ regulatory T cells (Tregs) and decreases the number of Th1 and T17 cells in vitro via increased TGF-beta-mediated Smad3 activity and reduces IFN-gamma-induced STAT1 signaling. In vivo, caerulomycin A (10 mg/kg) reduces IL-6, TNF-alpha, and IFN-gamma production, inflammation, and synovitis in a mouse model of collagen-induced arthritis. Caerulomycin A suppresses the differentiation of Th2 cells and reduces levels of IL-4, IL-5, IL-13, and IgE and eosinophil lung infiltration in a mouse model of ovalbumin-induced asthma. It also increases production of Tregs, reduces production of Th1, Th17, and CD8 T cells, and reduces disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).Formal Name: (E)-4-methoxy-[2,2'-bipyridine]-6-carboxaldehyde oxime. CAS Number: 21802-37-9. Molecular Formula: C12H11N3O2. Formula Weight: 229.2. Purity: >98%. Formulation: (Request formulation change), A solid. SMILES: COC1=CC(/C=N/O)=NC(C2=NC=CC=C2)=C1. InChi Code: InChI=1S/C12H11N3O2/c1-17-10-6-9(8-14-16)15-12(7-10)11-4-2-3-5-13-11/h2-8,16H,1H3/b14-8+. InChi Key: JCTRJRHLGOKMCF-RIYZIHGNSA-N. Origin: Bacterium/Streptomyces sp..