Butenafine (hydrochloride)

Butenafine is a benzylamine antifungal agent that has broad-spectrum activity against 87 strains of dermatophytes (MICs = 0.0015-0.05 µg/ml), 15 strains of Aspergillus (MICs = 0.025-0.78 µg/ml), 4 strains of Cryptococcus (MICs = 0.78-1.56 µg/ml), and 67 strains of Candida (MICs = 3.13 to >100 µg/ml). It acts by inhibiting squalene epoxidase. Butenafine (50 µM) inhibits the synthesis of ergosterol (Cay-19850), a sterol in the cell membranes of fungi. Formulations containing butenafine have been used in the treatment of tinea pedis, tinea corporis, and tinea cruris.Formal Name: N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-1-naphthalenemethanamine, monohydrochloride. CAS Number: 101827-46-7. Molecular Formula: C23H27N . HCl. Formula Weight: 353.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: CN(CC1=CC=C(C(C)(C)C)C=C1)CC2=C3C(C=CC=C3)=CC=C2.Cl. InChi Code: InChI=1S/C23H27N.ClH/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20,/h5-15H,16-17H2,1-4H3,1H. InChi Key: LJBSAUIFGPSHCN-UHFFFAOYSA-N.