Bromodiphenhydramine (hydrochloride)

Bromodiphenhydramine is a histamine H1 receptor antagonist. It induces histamine release in isolated guinea pig lung when used at a concentration of 1 mM but completely prevents ovalbumin-induced histamine release in lungs isolated from ovalbumin-sensitized guinea pigs when used at concentrations of 100 and 200 µg/ml. Bromodiphenhydramine (17 mg/kg) inhibits formalin-induced paw edema in rats. It increases survival in a mouse model of systemic S. typhimurium infection when administered at doses of 1.5 and 3 mg/kg.Formal Name: 2-[(4-bromophenyl)phenylmethoxy]-N,N-dimethyl-ethanamine, monohydrochloride. CAS Number: 1808-12-4. Synonyms: Bromazine, NSC 36113. Molecular Formula: C17H20BrNO . HCl. Formula Weight: 370.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 229 nm. SMILES: CN(C)CCOC(C1=CC=C(Br)C=C1)C2=CC=CC=C2.Cl. InChi Code: InChI=1S/C17H20BrNO.ClH/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15,/h3-11,17H,12-13H2,1-2H3,1H. InChi Key: ZQDJSWUEGOYDGT-UHFFFAOYSA-N.