BRD9539

BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 µM. It inhibits polycomb repressive complex 2 (PRC2) to a similar extent with 54 and 43% activity remaining for G9a and PRC2, respectively, when used at a concentration of 10 µM. It is selective for G9a and PRC2 over SU39H1 and NDMT1 up to a concentration of 40 µM. It is more potent than BRD4770 (Cay-11787) in enzyme assays but has no activity in cell-based assays when used at concentrations of 5 and 10 µM.Formal Name: 2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid. CAS Number: 1374601-41-8. Molecular Formula: C24H21N3O3. Formula Weight: 399.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 205, 230, 270, 329 nm. SMILES: O=C(C1=CC=CC=C1)NC2=NC3=CC(C(O)=O)=CC=C3N2CCCC4=CC=CC=C4. InChi Code: InChI=1S/C24H21N3O3/c28-22(18-11-5-2-6-12-18)26-24-25-20-16-19(23(29)30)13-14-21(20)27(24)15-7-10-17-8-3-1-4-9-17/h1-6,8-9,11-14,16H,7,10,15H2,(H,29,30)(H,25,26,28). InChi Key: WPXMEOBILYVKBC-UHFFFAOYSA-N.